Nakamura Kohei, Nakayama Kentaro, Nagaoka Risa, Nishisako Kiyoka, Ishikawa Masako, Katagiri Hiroshi, Ishibashi Tomoka, Sato Emi, Amano Chika, Kyo Satoru
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan.
Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan.
Oncol Lett. 2017 Jan;13(1):263-266. doi: 10.3892/ol.2016.5444. Epub 2016 Nov 30.
Malignant peritoneal mesotheliomas (MPMs) are rare and progressive tumors, which may present similarly to primary peritoneal carcinoma or ovarian carcinoma (OC). The current study reports two cases of MPM that initially presented with the features of OC, for which paired box 8 (PAX8) immunostaining was found to be useful for diagnosis. The two patients were women, aged 58 and 56 years, respectively. The primary presenting symptoms and clinical findings included prolonged abdominal pain, abdominal swelling and cough. The two cases were initially diagnosed as OC and were treated with primary debulking surgery. The patient in case 1 had no history of asbestos exposure, while the patient in case 2 did. Final diagnoses were determined based on histological and immunohistochemical results, which included negative PAX8 immunostaining, and which were consistent with MPM. The present cases demonstrated that PAX8 negativity may be a useful diagnostic biomarker for differentiating MPM from OC.
恶性腹膜间皮瘤（MPM）是罕见的进展性肿瘤，其表现可能与原发性腹膜癌或卵巢癌（OC）相似。本研究报告了两例最初表现为OC特征的MPM病例，发现配对盒8（PAX8）免疫染色对诊断有用。两名患者均为女性，年龄分别为58岁和56岁。主要的首发症状和临床发现包括持续性腹痛、腹部肿胀和咳嗽。这两例最初均被诊断为OC，并接受了初次肿瘤细胞减灭术。病例1的患者无石棉接触史，而病例2的患者有。最终诊断基于组织学和免疫组化结果确定，其中包括PAX8免疫染色阴性，且与MPM一致。本病例表明，PAX8阴性可能是区分MPM与OC的有用诊断生物标志物。
