NEDD4-1和PTEN表达与垂体腺瘤侵袭能力的相关性
Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.
作者信息
Zhang Jing, Li Xin, Zhang Yanyan
机构信息
Department of Neurosurgery, Heze Municipal Hospital, Heze, Shandong 274000, P.R. China.
Department of Neurosurgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China.
出版信息
Mol Clin Oncol. 2017 Jan;6(1):96-100. doi: 10.3892/mco.2016.1092. Epub 2016 Nov 24.
The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non-invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4-1 and PTEN was determined by immunohistochemistry. NEDD4-1 was revealed to be located in the nucleus and cytoplasm, whereas PTEN was only located in the cytoplasm. Furthermore, expression of NEDD4-1 was higher in pituitary adenomas compared with normal pituitary tissues (P<0.05), and higher in the invasive group compared with the non-invasive group, whereas the opposite trend was observed for PTEN. There was a strong negative correlation between NEDD4-1 and PTEN expression, indicating a dependency between the two and an association with invasiveness. In conclusion, NEDD4-1 may serve as a diagnostic and prognostic factor, and as a novel therapeutic target, in pituitary adenomas.
本研究的目的是将神经前体细胞表达的发育下调蛋白4-1（NEDD4-1）和第10号染色体缺失的磷酸酶及张力蛋白同源物（PTEN）的表达与垂体腺瘤的侵袭能力相关联。总共50例垂体腺瘤组织和10例正常垂体组织被分为侵袭组（26例）、非侵袭组（24例）和正常组（10例）。通过免疫组织化学法测定NEDD4-1和PTEN的表达。结果显示，NEDD4-1定位于细胞核和细胞质，而PTEN仅定位于细胞质。此外，与正常垂体组织相比，垂体腺瘤中NEDD4-1的表达更高（P<0.05），与非侵袭组相比，侵袭组中NEDD4-1的表达更高，而PTEN则呈现相反的趋势。NEDD4-1与PTEN表达之间存在强负相关，表明两者之间存在依赖性且与侵袭性相关。总之，NEDD4-1可能作为垂体腺瘤的诊断和预后因素以及新的治疗靶点。
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