近年来，在鉴定参与登革热病毒复制的宿主因子方面取得了进展。
Recent advances in the identification of the host factors involved in dengue virus replication.
机构信息
Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China.
出版信息
Virol Sin. 2017 Feb;32(1):23-31. doi: 10.1007/s12250-016-3902-6. Epub 2017 Jan 24.
Abstract
Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
摘要
登革热病毒（DENV）属于黄病毒科黄病毒属，主要通过埃及伊蚊和白纹伊蚊传播。DENV 的生命周期包括附着、内吞、蛋白质翻译、RNA 合成、组装、出芽和成熟。最近的研究表明，多种宿主因子，包括细胞蛋白和 microRNAs，正或负调控 DENV 的复制过程。本综述总结了 2014 年至 2016 年间鉴定参与 DENV 生命周期和登革热感染的宿主因子的最新发现。
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