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机器人辅助腹腔镜下睾丸肿瘤腹膜后淋巴结清扫术

Robot - assisted laparoscopic retroperitoneal lymph node dissection in testicular tumor.

作者信息

Torricelli Fabio C M, Jardim Denis, Guglielmetti Giuliano B, Patel Vipul, Coelho Rafael F

机构信息

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brasil.

Instituto do Câncer do Estado de São Paulo (ICESP), SP, Brasil.

出版信息

Int Braz J Urol. 2017 Jan-Feb;43(1):171. doi: 10.1590/S1677-5538.IBJU.2015.0436.

Abstract

INTRODUCTION AND OBJECTIVE

Retroperitoneal lymph node dissection (RPLND) is indicated for patients with non-seminomatous germ cell tumor (NSGCT) with residual disease after chemotherapy. Although the gold standard approach is still the open surgery, few cases of robot-assisted laparoscopic RPLND have been described. Herein, we aim to present the surgical technique for robot-assisted laparoscopic RPLND.

PATIENT AND METHOD

A 30 year-old asymptomatic man presented with left testicular swelling for 2 months. Physical examination revealed an enlarged and hard left testis. Alpha-fetoprotein (>1000ng/mL) and beta-HCG (>24.000U/L) were increased. Beta-HCG increased to >112.000U/L in less than one month. The patient underwent a left orchiectomy. Pathological examination showed a mixed NSGCT (50% embryonal carcinoma; 30% teratoma; 10% yolk sac; 10% choriocarcinoma). Computed tomography scan revealed a large tumor mass close to the left renal hilum (10x4x4cm) and others enlarged paracaval and paraortic lymph nodes (T2N3M1S3-stage III). Patient was submitted to 4 cycles of BEP with satisfactory response. Residual mass was suggestive of teratoma. Based on these findings, he was submitted to a robot-assisted RPLND.

RESULTS

RPLND was uneventfully performed. Operative time was 3.5 hours. Blood loss was minimal, and there were no intra- or postoperative complications. The patient was discharged from hospital in the 1st postoperative day. Pathological examination showed a pure teratoma. After 6 months of follow-up, patient is asymptomatic with an alpha-fetoprotein of 2.9ng/mL and an undetectable beta-HCG.

CONCLUSION

Robot-assisted laparoscopic RPLND is a feasible procedure with acceptable morbidity even for post chemotherapy patients when performed by an experienced surgeon.

摘要

引言与目的

对于化疗后仍有残留病灶的非精原细胞性生殖细胞肿瘤(NSGCT)患者,需行腹膜后淋巴结清扫术(RPLND)。尽管金标准术式仍是开放手术,但机器人辅助腹腔镜RPLND的病例报道较少。在此,我们旨在介绍机器人辅助腹腔镜RPLND的手术技术。

患者与方法

一名30岁无症状男性,左侧睾丸肿大2个月。体格检查发现左侧睾丸增大且质地坚硬。甲胎蛋白(>1000ng/mL)和β-HCG(>24,000U/L)升高。β-HCG在不到1个月内升至>112,000U/L。患者接受了左侧睾丸切除术。病理检查显示为混合性NSGCT(50%胚胎癌;30%畸胎瘤;10%卵黄囊瘤;10%绒毛膜癌)。计算机断层扫描显示左肾门附近有一个大肿瘤块(10×4×4cm),以及其他增大的腔静脉旁和主动脉旁淋巴结(T2N3M1S3-III期)。患者接受了4个周期的BEP化疗,反应良好。残留肿块提示为畸胎瘤。基于这些发现,他接受了机器人辅助RPLND。

结果

RPLND手术顺利完成。手术时间为3.5小时。失血极少,术中及术后均无并发症。患者术后第1天出院。病理检查显示为纯畸胎瘤。随访6个月后,患者无症状,甲胎蛋白为2.9ng/mL,β-HCG检测不到。

结论

对于化疗后的患者,由经验丰富的外科医生进行机器人辅助腹腔镜RPLND是一种可行的手术,发病率可接受。

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