Stallone D, Nicolaidis S
CNRS UA 637, Laboratoire de Neurobiologie des Régulations, Collège de France, Paris.
Neurosci Lett. 1989 Jul 31;102(2-3):319-24. doi: 10.1016/0304-3940(89)90099-2.
The effect on feeding of antagonism of the serotonergic system was studied. Intraperitoneal injection of one of 8 doses of the serotonin antagonist metergoline (MET) (0.06-1.5 mg.kg-1) given prior to a 3 h food deprivation produced a significant dose-related increase in intake of a standard laboratory diet throughout a 2 h measurement period. A 1 mg/kg dose of MET administered prior to one of 3 isocaloric powdered diets a medium carbohydrate, a high carbohydrate, and a non-carbohydrate diet - produced a significant increase in the intake by rats of all 3 diets in the first hour after food presentation. However, in the second hour MET continued to increase consumption of the high carbohydrate diet, whereas intakes of the medium carbohydrate and non-carbohydrate diets were no longer affected by MET treatment. These data suggest that the serotonergic system is a tonic inhibitor of food intake and of carbohydrate preference.
研究了血清素能系统拮抗作用对进食的影响。在禁食3小时前腹腔注射8种剂量之一的血清素拮抗剂美替戈林（MET）（0.06 - 1.5毫克·千克⁻¹），在整个2小时的测量期内，标准实验室饮食的摄入量出现了显著的剂量相关增加。在三种等热量粉状饮食（中等碳水化合物、高碳水化合物和非碳水化合物饮食）之一之前给予1毫克/千克剂量的MET，在提供食物后的第一小时，大鼠对所有三种饮食的摄入量均显著增加。然而，在第二小时，MET继续增加高碳水化合物饮食的摄入量，而中等碳水化合物和非碳水化合物饮食的摄入量不再受MET处理的影响。这些数据表明，血清素能系统是食物摄入和碳水化合物偏好的一种紧张性抑制剂。
