极低出生体重儿宫内镁暴露与自发性肠穿孔的关联
Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants.
作者信息
Downey L C, Cotten C M, Hornik C P, Laughon M M, Tolia V N, Clark R H, Smith P B
机构信息
Division of Neonatology, Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC, USA.
出版信息
J Perinatol. 2017 Jun;37(6):641-644. doi: 10.1038/jp.2016.274. Epub 2017 Jan 26.
OBJECTIVE
The objective of this study is to determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants (⩽1000 g).
STUDY DESIGN
We identified all ELBW infants admitted to 1 of 323 neonatal intensive care units from 2007 to 2013. We used multivariable conditional logistic regression to compare outcomes in the first 21 days after birth between infants exposed and unexposed to magnesium in utero.
RESULTS
Of the 28 035 infants, 11 789 (42%) were exposed to antenatal magnesium (AM). There was no difference in the risk of SIP, odds ratio=1.08 (95% confidence interval; 0.91 to 1.29), between infants exposed and unexposed to AM. Mortality in the first 21 days after birth was lower in the magnesium-exposed infants, odds ratio=0.76 (0.70 to 0.83).
CONCLUSION
AM exposure in ELBW infants was not associated with increased risk of SIP.
目的
本研究的目的是确定极低出生体重（ELBW，≤1000克）婴儿产前暴露于镁是否与自发性肠穿孔（SIP）有关。
研究设计
我们确定了2007年至2013年期间入住323家新生儿重症监护病房中1家的所有ELBW婴儿。我们使用多变量条件逻辑回归来比较出生后头21天内子宫内暴露于镁和未暴露于镁的婴儿的结局。
结果
在28035名婴儿中，11789名（42%）产前暴露于镁（AM）。暴露于AM和未暴露于AM的婴儿之间，SIP风险没有差异，比值比=1.08（95%置信区间：0.91至1.29）。镁暴露婴儿出生后头21天的死亡率较低，比值比=0.76（0.70至0.83）。
结论
ELBW婴儿暴露于AM与SIP风险增加无关。
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