Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of Korea.
Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of Korea.
Pediatr Neonatol. 2021 Mar;62(2):202-207. doi: 10.1016/j.pedneo.2020.12.009. Epub 2021 Jan 1.
Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there are concerns regarding the effects of antenatal magnesium sulfate on neonates, especially regarding gastrointestinal morbidities. This study aims to explore the effects of antenatal magnesium sulfate on intestinal morbidities requiring surgery in preterm infants.
This was a retrospective cohort study of 181 preterm infants who were born at less than 28 weeks of gestational age. Subjects were categorized as infants exposed to antenatal magnesium sulfate and those not exposed to antenatal magnesium sulfate.
Antenatal magnesium sulfate was associated with a decreased risk of surgical conditions of the intestine (OR 0.393, 95% CI 0.170-0.905). The multivariate analysis showed that the duration of antenatal magnesium sulfate use was associated with surgical conditions of the intestine (adjusted OR 0.766, 95% CI 0.589-0.997). In the <26 weeks of gestational age subgroup, the use of antenatal magnesium sulfate was significantly associated with decreased intestinal morbidities requiring surgery (adjusted OR 0.234, 95% CI 0.060-0.922).
Antenatal magnesium sulfate use appears to have a protective effect on intestinal morbidities requiring surgery in preterm infants in a duration-dependent manner. Association of antenatal magnesium sulfate use and decreased intestinal morbidities requiring surgery was more distinct in preterm infants <26 weeks of gestational age.
产前硫酸镁被广泛用作保胎药物，用于治疗产妇抽搐和子痫前期的抽搐预防。最近的研究表明，产前使用硫酸镁与早产儿的神经发育结局改善有关。然而，人们对产前硫酸镁对新生儿的影响存在担忧，特别是对胃肠道并发症的影响。本研究旨在探讨产前硫酸镁对早产儿肠道并发症需要手术的影响。
这是一项回顾性队列研究，纳入了 181 名胎龄小于 28 周的早产儿。将研究对象分为暴露于产前硫酸镁和未暴露于产前硫酸镁的两组。
产前硫酸镁的使用与手术治疗的肠道疾病风险降低相关（OR 0.393，95%CI 0.170-0.905）。多变量分析显示，产前硫酸镁使用的持续时间与肠道手术条件相关（调整后的 OR 0.766，95%CI 0.589-0.997）。在胎龄<26 周的亚组中，产前硫酸镁的使用与降低需要手术的肠道并发症显著相关（调整后的 OR 0.234，95%CI 0.060-0.922）。
产前硫酸镁的使用似乎以时间依赖的方式对早产儿需要手术的肠道并发症具有保护作用。在胎龄<26 周的早产儿中，产前硫酸镁的使用与减少需要手术的肠道并发症之间的关联更为明显。
