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It's All in the Delivery: Improving AAV Transfection Efficiency with Exosomes.一切都在于递送：利用外泌体提高腺相关病毒转染效率
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Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles.通过1型腺相关病毒（AAV）载体递送谷氨酸脱羧酶500自身抗原可预防非肥胖糖尿病（NOD）小鼠患糖尿病：转导效率并非起重要作用。
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Recent developments in adeno-associated virus vector technology.腺相关病毒载体技术的最新进展。
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Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes.腺相关载体表达人多药耐药和葡萄糖脑苷脂酶cDNA：腺相关病毒序列的高效启动子活性及通过脂质体进行体内递送
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Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice.通过直接注射到肝实质中，腺相关病毒介导的胰岛素基因转染缺陷可降低糖尿病小鼠的血糖。
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Extracellular Vesicles-Mimetic Encapsulation Improves Oncolytic Viro-Immunotherapy in Tumors With Low Coxsackie and Adenovirus Receptor.细胞外囊泡模拟封装改善了柯萨奇病毒和腺病毒受体低表达肿瘤中的溶瘤病毒免疫疗法。
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本文引用的文献

1
Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.利用外泌体相关腺相关病毒向内耳毛细胞进行基因传递来恢复听力
Mol Ther. 2017 Feb 1;25(2):379-391. doi: 10.1016/j.ymthe.2016.12.010. Epub 2017 Jan 9.
2
Application of Mouse Models to Research in Hearing and Balance.小鼠模型在听力与平衡研究中的应用
J Assoc Res Otolaryngol. 2016 Dec;17(6):493-523. doi: 10.1007/s10162-016-0589-1. Epub 2016 Oct 17.
3
On the Distant Horizon--Medical Therapy for Sensorineural Hearing Loss.遥远的前景——感音神经性听力损失的医学治疗
Otolaryngol Clin North Am. 2015 Dec;48(6):1149-65. doi: 10.1016/j.otc.2015.07.012. Epub 2015 Sep 26.
4
Tmc gene therapy restores auditory function in deaf mice.Tmc基因疗法可恢复耳聋小鼠的听觉功能。
Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996.
5
Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane.通过圆窗膜将病毒介导的基因递送至小鼠内耳的手术方法。
J Vis Exp. 2015 Mar 16(97):52187. doi: 10.3791/52187.
6
Treating hearing disorders with cell and gene therapy.用细胞和基因疗法治疗听力障碍。
J Neural Eng. 2014 Dec;11(6):065001. doi: 10.1088/1741-2560/11/6/065001.
7
Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice.病毒表达的连接蛋白26可恢复条件性Gjb2基因敲除小鼠耳蜗中的缝隙连接功能。
Gene Ther. 2014 Jan;21(1):71-80. doi: 10.1038/gt.2013.59. Epub 2013 Nov 14.
8
A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.此前未被描述的基因Tmhs中的一个错义突变是匆匆忙忙（hscy）小鼠耳聋的根本原因。
Proc Natl Acad Sci U S A. 2005 May 31;102(22):7894-9. doi: 10.1073/pnas.0500760102. Epub 2005 May 19.
9
Expression of adeno-associated virus integrated transgene within the mammalian vestibular organs.腺相关病毒整合转基因在哺乳动物前庭器官中的表达。
Am J Otol. 1998 May;19(3):390-5.

It's All in the Delivery: Improving AAV Transfection Efficiency with Exosomes.

作者信息

Martin Donna M, Raphael Yehoash

机构信息

Departments of Pediatrics and Human Genetics, The University of Michigan, 1150 W. Medical Ctr. Dr., 3520D MSRB-I, Ann Arbor, MI 48109-5652.

Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, The University of Michigan, 9220B MSRB-III, Ann Arbor, MI 48109-5648.

出版信息

Mol Ther. 2017 Feb 1;25(2):309-311. doi: 10.1016/j.ymthe.2017.01.004. Epub 2017 Jan 23.

DOI:10.1016/j.ymthe.2017.01.004
PMID:28126363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5368841/
Abstract
摘要