It's All in the Delivery: Improving AAV Transfection Efficiency with Exosomes.
作者信息
Martin Donna M, Raphael Yehoash
机构信息
Departments of Pediatrics and Human Genetics, The University of Michigan, 1150 W. Medical Ctr. Dr., 3520D MSRB-I, Ann Arbor, MI 48109-5652.
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, The University of Michigan, 9220B MSRB-III, Ann Arbor, MI 48109-5648.
出版信息
Mol Ther. 2017 Feb 1;25(2):309-311. doi: 10.1016/j.ymthe.2017.01.004. Epub 2017 Jan 23.
Abstract
摘要
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2
Application of Mouse Models to Research in Hearing and Balance.小鼠模型在听力与平衡研究中的应用
J Assoc Res Otolaryngol. 2016 Dec;17(6):493-523. doi: 10.1007/s10162-016-0589-1. Epub 2016 Oct 17.
3
On the Distant Horizon--Medical Therapy for Sensorineural Hearing Loss.遥远的前景——感音神经性听力损失的医学治疗
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4
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