Talreja Shyam Manoharlal, Yadav Sher Singh, Tomar Vinay, Agarwal Neeraj, Jaipal Usha, Priyadarshi Shivam
Department of Urology, SMS Medical College and Hospital, Jaipur, India.
Cent European J Urol. 2016;69(4):417-424. doi: 10.5173/ceju.2016.808. Epub 2016 Nov 30.
Spongiofibrosis assessment is critically important in the evaluation of anterior urethral strictures as its severity is directly proportional to stricture recurrence and thus affects management. Retrograde urethrography (RGU) is ineffective in the evaluation of spongiofibrosis. Sonourethrography (SUG) delineates it but does not accurately estimate its depth. Real-time elastography (RTE), a newer technique that not only attempts a qualitative but also quantitative estimation of spongiofibrosis (tissue stiffness) which results due to underlying pathological processes.
In the present study, various elastographic patterns and strain ratios in anterior urethral stricture patients were studied and compared to operative and histopathological findings. Sixty-three RGU diagnosed anterior urethral stricture cases were taken and re-evaluated by SUG and SE by another radiologist who was blinded to the findings of the RGU. Strain patterns and ratios of spongiofibrotic segments were documented and compared with operative findings as gold standard.
Blue pattern on RTE showed 100% concordance with severe fibrosis as evaluated against histopathological findings whereas green pattern showed 87.5% concordance with moderate degree of fibrosis. Severe degree of fibrosis cases, confirmed on histopathology had a significantly higher mean strain ratio (10.51 ±2.297) as compared to moderate degree (6.33 ±2.353) (p <0.001 S).
Real time sonoelastography in the evaluation of spongiofibrosis not only assesses it qualitatively but also quantifies it. Strain ratios are statistically better indicators for estimating spongiofibrosis.
海绵体纤维化评估在评估前尿道狭窄中至关重要,因为其严重程度与狭窄复发直接相关,从而影响治疗管理。逆行尿道造影(RGU)在评估海绵体纤维化方面无效。超声尿道造影(SUG)可描绘出海绵体纤维化,但无法准确估计其深度。实时弹性成像(RTE)是一种较新的技术,它不仅尝试对海绵体纤维化(组织硬度)进行定性评估,还能进行定量评估,而这种纤维化是由潜在病理过程导致的。
在本研究中,对前尿道狭窄患者的各种弹性成像模式和应变率进行了研究,并与手术及组织病理学结果进行比较。选取63例经RGU诊断为前尿道狭窄的病例,由另一位对RGU结果不知情的放射科医生通过SUG和SE进行重新评估。记录海绵体纤维化节段的应变模式和比率,并与作为金标准的手术结果进行比较。
与组织病理学结果相比,RTE上的蓝色模式显示与严重纤维化的一致性为100%,而绿色模式显示与中度纤维化的一致性为87.5%。组织病理学确诊的严重纤维化病例的平均应变率(10.51±2.297)显著高于中度纤维化病例(6.33±2.353)(p<0.001 S)。
实时超声弹性成像在评估海绵体纤维化时不仅能进行定性评估,还能进行定量评估。应变率在统计学上是评估海绵体纤维化更好的指标。