Doix Aude-Clémence M, Roeleveld Karin, Garcia Jérémy, Lahaut Pauline, Tanant Véronique, Fournier-Mehouas Manuella, Desnuelle Claude, Colson Serge S, Sacconi Sabrina
From the Université Côte d'Azur, LAMHESS, Nice, France (A-CMD, MF-M, SSC); Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway (A-CMD, KR); Université Côte d'Azur, CHU (JG, PL, VT, MF-M, CD, SS); and Université Côte d'Azur, CNRS, INSERM, IRCAN (CD, SS), Nice, France.
Am J Phys Med Rehabil. 2017 Apr;96(4):e56-e63. doi: 10.1097/PHM.0000000000000705.
The aim of this study was to investigate the effects on motor function, muscle strength, and endurance of short-term neuromuscular electrical stimulation training of the tibialis anterior muscles in patients with facioscapulohumeral muscular dystrophy type 1 (FSHD1) in comparison with healthy controls.
This prospective study included 10 patients with FSHD1 and 10 healthy participants. Maximal voluntary isometric contraction of ankle dorsiflexion and a 2-min sustained dorsiflexion maximal voluntary contraction with surface electromyography recordings of the tibialis anterior and the soleus muscles were measured and motor function clinical tests were performed before and after the training period.
No significant short term training effect was found in any of the investigated variables for either group, although a tendency towards an increase was noted for the manual muscle testing of the FSHD1. Patients with FSHD1 showed lower maximal voluntary contraction force and lower maximal tibialis anterior surface electromyography amplitude than healthy participants. During the 2-min sustained maximal voluntary contraction, the percentage of force loss was lower for the FSHD1 patients, suggesting that they were experiencing a lower amount of muscle fatigue compared to the healthy participant group.
The present neuromuscular electrical stimulation protocol was not strenuous enough and/or the parameters of stimulation were not adequate to improve dorsiflexion strength, muscle endurance, and motor function in FSHD1 patients and healthy participants.
本研究旨在调查1型面肩肱型肌营养不良症（FSHD1）患者与健康对照相比，胫前肌短期神经肌肉电刺激训练对运动功能、肌肉力量和耐力的影响。
这项前瞻性研究纳入了10例FSHD1患者和10名健康参与者。在训练期前后测量踝关节背屈的最大自主等长收缩以及2分钟持续背屈最大自主收缩，并记录胫前肌和比目鱼肌的表面肌电图，同时进行运动功能临床测试。
两组在任何研究变量中均未发现显著的短期训练效果，尽管FSHD1患者的徒手肌力测试有增加的趋势。FSHD1患者的最大自主收缩力和胫前肌表面肌电图最大振幅均低于健康参与者。在2分钟持续最大自主收缩期间，FSHD1患者的力量损失百分比更低，这表明与健康参与者组相比，他们经历的肌肉疲劳程度更低。
目前的神经肌肉电刺激方案强度不够大，和/或刺激参数不足以改善FSHD1患者和健康参与者的背屈力量、肌肉耐力和运动功能。
