mRNA 调控的长尾现象。

The Long Tail of mRNA Regulation.

出版信息

Cell. 2017 Jan 26;168(3):335-338. doi: 10.1016/j.cell.2017.01.015.

DOI:10.1016/j.cell.2017.01.015

Abstract

Long stretches of RNA trail after the coding region in most eukaryotic mRNAs. These 3' untranslated regions (3' UTRs) hold the key for many aspects of regulated gene expression, influencing mRNA stability, protein synthesis, and ultimately protein function. Lara Szewczak asked Rachel Green, Ian Macrae, and Christine Mayr about how dynamic regulation by proteins and microRNAs works within 3' UTRs. An annotated excerpt of the conversation appears below, and the full conversation is available with the article online.

摘要

在大多数真核生物 mRNA 的编码区后面是很长的 RNA 序列。这些 3' 非翻译区（3' UTRs）是调控基因表达的许多方面的关键，影响 mRNA 的稳定性、蛋白质合成，最终影响蛋白质功能。Lara Szewczak 询问了 Rachel Green、Ian Macrae 和 Christine Mayr 有关蛋白质和 microRNA 如何在 3' UTR 内进行动态调控的问题。下面是对话的注释摘录，完整的对话可在网上文章中查看。