Meakin A S, Saif Z, Jones A R, Aviles P F Valenzula, Clifton V L
Mater Medical Research Institute, University of Queensland, Brisbane, Australia.
Mater Medical Research Institute, University of Queensland, Brisbane, Australia.
Placenta. 2017 Jun;54:17-23. doi: 10.1016/j.placenta.2017.01.123. Epub 2017 Jan 21.
Asthma is a highly prevalent chronic medical condition affecting an estimated 12% of pregnant, women each year, with prevalence of asthma greatest (up to 16%) among the socially disadvantaged. Maternal asthma is associated with significant perinatal morbidity and mortality including preterm births, neonatal hospitalisations and low birthweight outcomes each year. We have identified that the placenta adapts to the presence of chronic, maternal asthma during pregnancy in a sex specific manner that may confer sex differences in fetal outcome. The male fetus was at greater risk of a poor outcome than a female fetus in the presence of maternal asthma and an acute inflammatory event such as an asthma exacerbation. This review will examine the role of sex specific differences in placental function on fetal growth and survival.
哮喘是一种高度流行的慢性疾病，估计每年影响12%的孕妇，且在社会弱势群体中哮喘患病率最高（达16%）。每年，孕产妇哮喘与显著的围产期发病率和死亡率相关，包括早产、新生儿住院和低出生体重等情况。我们已经确定，胎盘在孕期会以性别特异性方式适应慢性孕产妇哮喘的存在，这可能导致胎儿结局出现性别差异。在孕产妇哮喘以及诸如哮喘加重等急性炎症事件存在的情况下，男性胎儿比女性胎儿出现不良结局的风险更高。本综述将探讨胎盘功能的性别特异性差异对胎儿生长和存活的作用。
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