Stevens Danielle R, Yeung Edwina, Hinkle Stefanie N, Grobman William, Williams Andrew, Ouidir Marion, Kumar Rajesh, Lipsky Leah M, Rohn Matthew C H, Kanner Jenna, Sherman Seth, Chen Zhen, Mendola Pauline
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park.
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
J Allergy Clin Immunol Glob. 2023 Aug;2(3). doi: 10.1016/j.jacig.2023.100122. Epub 2023 May 30.
Asthma affects 10% of pregnancies and may influence offspring health, including infant size and body composition, through hypoxic and inflammatory pathways.
We sought to determine associations between maternal asthma and asthma phenotypes during pregnancy and infant size and body composition.
The B-WELL-Mom study (2015-19) is a prospective cohort of 418 pregnant persons with and without asthma recruited in the first trimester of pregnancy from 2 US obstetric clinics. Exposures were maternal self-reported active asthma (n = 311) or no asthma (n = 107), and asthma phenotypes were classified on the bases of atopy, onset, exercise induced, control, severity, symptomology, and exacerbations. Outcomes were infant weight, length, head circumference, and skinfold measurements at birth and postnatal follow-up, as well as fat and lean mass assessed by air displacement plethysmography at birth. Adjusted multivariable linear regression examined associations of maternal asthma and asthma phenotypes with infant outcomes.
Offspring were born at a mean ± SD of 38 ± 2.3 weeks' gestation and were 18 ± 2.2 weeks of age at postnatal follow-up. Infants of participants with asthma had a mean ± SD fat mass of 11.0 ± 4.2%, birth weight of 3045.8 ± 604.3 g, and postnatal follow-up weight of 6696.4 ± 964.2 g, which were not different from infants of participants without asthma (respectively, β [95% confidence interval]: -0.1 [-1.4, 1.3], -26.7 [-156.9, 103.4], and 107.5 [-117.3, 332.3]). Few associations were observed between asthma or asthma phenotypes and infant size or body composition.
In a current obstetric cohort, maternal asthma during pregnancy was not associated with differential infant size or body composition.
哮喘影响10%的孕期女性，并可能通过缺氧和炎症途径影响后代健康，包括婴儿大小和身体组成。
我们试图确定孕期母亲哮喘及哮喘表型与婴儿大小和身体组成之间的关联。
B-WELL-Mom研究（2015 - 2019年）是一项前瞻性队列研究，从美国2家产科诊所招募了418名怀孕女性，她们有的患有哮喘，有的没有。暴露因素为母亲自我报告的活动性哮喘（n = 311）或无哮喘（n = 107），哮喘表型根据特应性、发病情况、运动诱发、控制情况、严重程度、症状和加重情况进行分类。结局指标为出生时及产后随访时婴儿的体重、身长、头围和皮褶测量值，以及出生时通过空气置换体积描记法评估的脂肪量和去脂体重。调整后的多变量线性回归分析了母亲哮喘及哮喘表型与婴儿结局之间的关联。
后代平均在孕38 ± 2.3周出生，产后随访时年龄为18 ± 2.2周。患有哮喘的参与者的婴儿平均脂肪量为11.0 ± 4.2%，出生体重为3045.8 ± 604.3克，产后随访体重为6696.4 ± 964.2克，与没有哮喘的参与者的婴儿没有差异（分别为β[95%置信区间]：-0.1[-1.4, 1.3]，-26.7[-156.9, 103.4]，以及107.5[-117.3, 332.3]）。在哮喘或哮喘表型与婴儿大小或身体组成之间未观察到明显关联。
在当前的产科队列中，孕期母亲哮喘与婴儿大小或身体组成的差异无关。
