Hedlund B, Andersen P
Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Pharmacol Toxicol. 1989 Sep;65(3):185-8. doi: 10.1111/j.1600-0773.1989.tb01153.x.
Effects of alaproclate, an antidepressive substance and 5-HT uptake blocker, was studied using intracellular and extracellular recording techniques. Possible effects on the excitability of CA1 pyramidal cells in slices from rat hippocampus were explored. Alaproclate increased the probability of firing to an orthodromic input, increased the membrane resistance and prolonged the action potential. Increased excitability was also observed in extracellular recording experiments. It is suggested that these effects are due to depression of potassium channels in the membrane.
使用细胞内和细胞外记录技术研究了抗抑郁物质和5-羟色胺摄取阻滞剂阿那普明的作用。探讨了其对大鼠海马切片中CA1锥体细胞兴奋性的可能影响。阿那普明增加了对顺向输入放电的概率，增加了膜电阻并延长了动作电位。在细胞外记录实验中也观察到兴奋性增加。提示这些作用是由于膜中钾通道的抑制所致。
