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[一例通过肿瘤减灭术及术后化疗成功治疗的原发性腹膜癌病例]

[A Case of Primary Peritoneal Cancer Successfully Treated with Debulking Surgery and Postoperative Chemotherapy].

作者信息

Maeda Koki, Tabata Masami, Moriyama Taiki, Sakamoto Tatsuya, Fujimura Yu, Ohsawa Ichiro, Kato Kenji, Iwata Makoto, Sanda Takayuki

机构信息

Dept. of Surgery, Matsusaka Central General Hospital.

出版信息

Gan To Kagaku Ryoho. 2016 Nov;43(12):2115-2117.

Abstract

A 52-year-old woman with abdominal pain and a feeling of incomplete evacuation visited a local clinic. Enlargement of the right ovary was detected, and the patient was referred to the gynecological department of our hospital. CT and MRI revealed a round-shaped mass, 8 cm in diameter, with cystic and solid components in the Douglas pouch. The patient underwent a laparotomy under the diagnosis of ovarian cancer. Intraoperatively, both the ovaries appeared normal and the tumor strongly adhered to the rectum and uterus. An exploratory laparotomy was performed; the tumor was identified as unresectable, and the patient was referred to our department after the surgery. PET-CT revealed nodules in the liver and peritoneum, in addition to the main tumor. Gastrointestinal endoscopy and immunohistochemical examination of a needle biopsy of the main tumor did not lead to the identification of the primary lesion. Thus, debulking surgery was performed to alleviate the patient's complaints. Histologically, the tumor was diagnosed as a primary peritoneal clear cell carcinoma. One month after surgery, multiple liver metastases and swelling of the peritoneal lymph nodes occurred. Six courses of dose-dense TC therapy were administered, and the patient achieved a complete response. At 8 months after surgery, the patient is still alive without tumor recurrence.

摘要

一名52岁女性因腹痛及排便不尽感前往当地诊所就诊。检查发现右侧卵巢增大,遂转诊至我院妇科。CT和MRI检查显示,Douglas窝有一个直径8厘米的圆形肿块,包含囊性和实性成分。患者在诊断为卵巢癌后接受了剖腹手术。术中发现双侧卵巢外观正常,但肿瘤与直肠和子宫紧密粘连。遂进行了剖腹探查;发现肿瘤无法切除,术后患者转诊至我科。PET-CT检查显示,除了主要肿瘤外,肝脏和腹膜也有结节。对主要肿瘤进行的胃肠内镜检查和针吸活检的免疫组化检查均未发现原发灶。因此,为缓解患者症状进行了肿瘤减灭术。组织学检查诊断该肿瘤为原发性腹膜透明细胞癌。术后1个月,出现多处肝转移及腹膜淋巴结肿大。给予六个疗程的剂量密集型TC方案化疗,患者达到完全缓解。术后8个月,患者仍存活,无肿瘤复发。

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