Muroya Takahiro, Wajima Naoki, Akasaka Harue, Hasebe Tatsuya, Yakoshi Yuta, Yachi Takafumi, Akaishi Takanobu, Sato Kentaro, Mitsuhashi Yuto, Hakamada Kenichi
Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2016 Nov;43(12):2184-2186.
Esophageal neuroendocrine carcinoma is relatively rare and the prognosis is poor owing to its aggressive malignancy. We experienced a case of neuroendocrine carcinoma of the esophagus treated with neoadjuvant chemotherapy of 5-fluorouracil plus cisplatin. A 71-year-old man was diagnosed with esophageal carcinoma(clinical T3N1M0, Stage III ). He received neoadjuvant chemotherapy comprising 5-fluorouracil plus cisplatin, followed by subtotal esophagectomy with dissection of 3 regional lymph nodes. Immunohistochemical findings were synaptophysin-positive, CD56-positive, Ki-67(labeling index) B90%. The final diagnosis was neuroendocrine carcinoma, categorized as CT-pT1a-MM, pN0, Stage 0. The pathological response to neoadjuvant chemotherapy was Grade 2. The patient is alive 8 months after esophagectomy without metastasis.
食管神经内分泌癌相对罕见，因其恶性程度高，预后较差。我们遇到一例食管神经内分泌癌患者，接受了5-氟尿嘧啶联合顺铂的新辅助化疗。一名71岁男性被诊断为食管癌（临床T3N1M0，Ⅲ期）。他接受了包含5-氟尿嘧啶联合顺铂的新辅助化疗，随后行食管次全切除术并清扫3个区域淋巴结。免疫组化结果显示突触素阳性、CD56阳性、Ki-67（标记指数）为90%。最终诊断为神经内分泌癌，分类为CT-pT1a-MM，pN0，0期。新辅助化疗的病理反应为2级。患者在食管切除术后8个月仍存活，无转移。
