肝胆疾病犬血清皮质类固醇诱导碱性磷酸酶同工酶的分析

Analysis of serum corticosteroid-induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases.

作者信息

Kojima K, Ohno K, Kanemoto H, Goto-Koshino Y, Fukushima K, Tsujimoto H

机构信息

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.

出版信息

J Small Anim Pract. 2017 May;58(5):257-262. doi: 10.1111/jsap.12623. Epub 2017 Jan 30.

DOI:10.1111/jsap.12623

PMID:28133732

Abstract

OBJECTIVE

To reveal the relationship between canine corticosteroid-induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases.

MATERIALS AND METHODS

Retrospective analysis of the relationship between serum corticosteroid-induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded.

RESULTS

Seventy-two dogs with hepatobiliary diseases were analysed. The serum corticosteroid-induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid-induced alkaline phosphatase percentage or activity.

CLINICAL SIGNIFICANCE

Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.

摘要