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血清γ-谷氨酰转移酶在犬类肝脏疾病诊断中的应用

Diagnostic use of serum gamma-glutamyltransferase in canine liver disease.

作者信息

Shull R M, Hornbuckle W

出版信息

Am J Vet Res. 1979 Sep;40(9):1321-4.

PMID:43109
Abstract

gamma-Glutamyltransferase (GGT) activity in canine kidney, pancreas, and liver is similar to previously reported values for other species. The low serum GGT activity in dogs (0 to 10 IU/L) may be related to relatively less liver GGT than in some other domestic animals. While determination of serum GGT in dogs may aid in the differentiation of sources of alkaline phosphatase, GGT alone appears to offer little in the diagnosis of canine liver disease. Clinical studies, as well as experimentally induced bile duct obstruction, have shown canine GGT increases to coincide with increases in alkaline phosphatase. The occasional benefit from knowledge of serum GGT in dogs would not seem to merit determination of GGT activity in routine serum chemistry panels for this species.

摘要

犬肾、胰腺和肝脏中的γ-谷氨酰转移酶(GGT)活性与先前报道的其他物种的值相似。犬血清GGT活性较低(0至10 IU/L)可能与肝脏GGT比其他一些家畜相对较少有关。虽然测定犬血清GGT可能有助于鉴别碱性磷酸酶的来源,但仅GGT在犬肝病诊断中似乎作用不大。临床研究以及实验性诱导的胆管阻塞表明,犬GGT升高与碱性磷酸酶升高同时出现。了解犬血清GGT偶尔带来的益处似乎不值得在该物种的常规血清化学检测中测定GGT活性。

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