由DNA共轭β-环肽自组装而成的DNA修饰人工病毒衣壳。
DNA-modified artificial viral capsids self-assembled from DNA-conjugated β-annulus peptide.
作者信息
Nakamura Yoko, Yamada Saki, Nishikawa Shoko, Matsuura Kazunori
机构信息
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, 680-8552, Japan.
出版信息
J Pept Sci. 2017 Jul;23(7-8):636-643. doi: 10.1002/psc.2967. Epub 2017 Jan 30.
β-Annulus peptides from tomato bushy stunt virus conjugated with DNAs (dA and dT ) at the C-terminal were synthesized. The DNA-modified β-annulus peptides self-assembled into artificial viral capsids with sizes of 45-160 nm. ζ-Potential measurements revealed that the DNAs were coated on the surface of artificial viral capsids. Fluorescence assays indicated that the DNAs on the artificial viral capsids were partially hybridized with the complementary DNAs. Moreover, the DNA-modified artificial viral capsids formed aggregates by adding complementary polynucleotides. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
合成了在C端与DNA（dA和dT）偶联的来自番茄丛矮病毒的β-环肽。DNA修饰的β-环肽自组装成尺寸为45 - 160纳米的人工病毒衣壳。ζ电位测量表明DNA包被在人工病毒衣壳表面。荧光测定表明人工病毒衣壳上的DNA与互补DNA部分杂交。此外，DNA修饰的人工病毒衣壳通过添加互补多核苷酸形成聚集体。版权所有© 2017欧洲肽学会和约翰·威利父子有限公司。
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