由阴离子β-环肽和阳离子脂质双层自组装而成的包膜人工病毒衣壳。

Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer.

作者信息

Furukawa Hiroto, Inaba Hiroshi, Inoue Fumihito, Sasaki Yoshihiro, Akiyoshi Kazunari, Matsuura Kazunori

机构信息

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan.

出版信息

Chem Commun (Camb). 2020 Jul 4;56(52):7092-7095. doi: 10.1039/d0cc02622k. Epub 2020 Jun 3.

DOI:10.1039/d0cc02622k

PMID:32490862

Abstract

Anionic artificial viral capsids were self-assembled from β-annulus-EE peptide, then complexed with lipid-bilayer-containing cationic lipids via electrostatic interaction to form enveloped artificial viral capsids. The critical aggregation concentration of the enveloped artificial viral capsid was significantly lower than that of the uncomplexed artificial viral capsid, indicating that the lipid bilayer stabilised the capsid structure.

摘要

阴离子人工病毒衣壳由β-环-EE肽自组装而成，然后通过静电相互作用与含脂质双层的阳离子脂质复合，形成包膜人工病毒衣壳。包膜人工病毒衣壳的临界聚集浓度显著低于未复合的人工病毒衣壳，这表明脂质双层稳定了衣壳结构。