Furukawa Hiroto, Inaba Hiroshi, Inoue Fumihito, Sasaki Yoshihiro, Akiyoshi Kazunari, Matsuura Kazunori
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan.
Chem Commun (Camb). 2020 Jul 4;56(52):7092-7095. doi: 10.1039/d0cc02622k. Epub 2020 Jun 3.
Anionic artificial viral capsids were self-assembled from β-annulus-EE peptide, then complexed with lipid-bilayer-containing cationic lipids via electrostatic interaction to form enveloped artificial viral capsids. The critical aggregation concentration of the enveloped artificial viral capsid was significantly lower than that of the uncomplexed artificial viral capsid, indicating that the lipid bilayer stabilised the capsid structure.
阴离子人工病毒衣壳由β-环-EE肽自组装而成，然后通过静电相互作用与含脂质双层的阳离子脂质复合，形成包膜人工病毒衣壳。包膜人工病毒衣壳的临界聚集浓度显著低于未复合的人工病毒衣壳，这表明脂质双层稳定了衣壳结构。
