Fatuzzo Pasquale, Zanoli Luca, Scollo Viviana, Portale Grazia, Gaudio Agostino, Pani Alessandra, Granata Antonio
G Ital Nefrol. 2016 Nov-Dec;33(6).
Magnesium is the second intracellular cation and the fourth most abundant mineral in the body. Low levels of magnesium have been associated with insulin resistance and type-2 diabetes mellitus, asthma, osteoporosis and chronic kidney disease (CKD). The use of proton pump inhibitors (PPIs) represents the most common cause of hypomagnesemia. The risk of hypomagnesemia, and consequently worsening of the renal function, is increased when diuretics are added to therapy in subjects treated with PPIs. Interestingly, diuretics and PPIs are two of the most used drugs in subjects with CKD. In this review, we described the mechanisms at the basis of the hypomagnesemia and the effect of this electrolyte disturbance in subjects with CKD.
镁是细胞内第二大阳离子，也是体内含量第四丰富的矿物质。低镁水平与胰岛素抵抗、2型糖尿病、哮喘、骨质疏松症和慢性肾脏病（CKD）有关。使用质子泵抑制剂（PPI）是低镁血症最常见的原因。在接受PPI治疗的患者中，添加利尿剂进行治疗时，低镁血症的风险以及肾功能恶化的风险会增加。有趣的是，利尿剂和PPI是CKD患者中最常用的两种药物。在本综述中，我们描述了低镁血症背后的机制以及这种电解质紊乱对CKD患者的影响。
