Messiha F S
Texas Tech University Health Sciences Center, School of Medicine, Lubbock.
Physiol Behav. 1989 Jul;46(1):85-8. doi: 10.1016/0031-9384(89)90327-2.
The effect of postnatal maternal exposure to CsCl on the newborn was studied in the mouse. Maternal ingestion of 1 mEq CsCl solution as the only drinking fluid began immediately after birth and the offspring were breast-fed until weaning. They were then separated from the nursing dams and remained Cs free for a subsequent 2 weeks prior to sacrifice. Maternal Cs exposure decreased the weanling body weight from controls and they attained normal body weight after 2 weeks of Cs-free period during development. Maternal Cs ingestion caused a reduction in offspring brain weight of both sexes compared to controls. The kidney weight of the developing female, but not male, offspring was also decreased from controls as a consequence of maternal Cs exposure. The offspring's hepatic alcohol and aldehyde dehydrogenase were not altered from controls as a function of maternal exposure to Cs salt. Little changes occurred in offspring heart lactate dehydrogenase by the maternal Cs treatment. The results suggest that maternal Cs exposure during breast-feeding affected body weight and the CNS of the offspring. The change noted in weanling kidney weight was sex dependent. These gross pathological changes in weanling organ weight were not apparent when maternal breast-feeding was eliminated. The data indicates that Cs adversely affected the newborn which was eliminated after cessation of the Cs exposure.
在小鼠中研究了产后母体暴露于氯化铯对新生儿的影响。母体摄入1 mEq氯化铯溶液作为唯一的饮用水，在出生后立即开始，后代一直母乳喂养至断奶。然后将它们与哺乳母鼠分开，在处死前的接下来2周内不再接触铯。母体接触铯使断奶幼崽体重低于对照组，并且在发育过程中经过2周的无铯期后它们达到了正常体重。与对照组相比，母体摄入铯导致两性后代脑重减轻。由于母体接触铯，发育中的雌性后代而非雄性后代的肾脏重量也低于对照组。后代肝脏中的乙醇和乙醛脱氢酶并未因母体接触铯盐而与对照组有所不同。母体铯处理对后代心脏乳酸脱氢酶影响很小。结果表明，母乳喂养期间母体接触铯会影响后代的体重和中枢神经系统。断奶幼崽肾脏重量的变化具有性别依赖性。当消除母体母乳喂养时，断奶幼崽器官重量的这些大体病理变化并不明显。数据表明，铯对新生儿有不利影响，在停止接触铯后这种影响会消除。
