来自患有中枢神经系统肿瘤的成年供体的胸部同种异体移植术后肿瘤传播风险——一项器官共享联合网络（UNOS）数据库研究

Risk of tumor transmission after thoracic allograft transplantation from adult donors with central nervous system neoplasm-A UNOS database study.

作者信息

Hynes Conor F, Ramakrishnan Karthik, Alfares Fahad A, Endicott Kendal M, Hammond-Jack Katrina, Zurakowski David, Jonas Richard A, Nath Dilip S

机构信息

Children's National Medical Center, Washington, USA.

出版信息

Clin Transplant. 2017 Apr;31(4). doi: 10.1111/ctr.12919. Epub 2017 Mar 2.

DOI:10.1111/ctr.12919

PMID:28135779

Abstract

BACKGROUND

We analyzed the UNOS database to better define the risk of transmission of central nervous system (CNS) tumors from donors to adult recipients of thoracic organs.

METHODS

Data were procured from the Standard Transplant Analysis and Research dataset files. Donors with CNS tumors were identified, and recipients from these donors comprised the study group (Group I). The remaining recipients of organs from donors who did not have CNS tumors formed the control group (Group II). Incidence of recipient CNS tumors, donor-related malignancies, and overall survival were calculated and compared in addition to multivariable logistic regression.

RESULTS

A cohort of 58 314 adult thoracic organ recipients were included, of which 337 received organs from donors who had documented CNS tumors (Group I). None of these recipients developed CNS tumors at a median follow-up of 72 months (IR: 30-130 months). Although overall mortality in terms of the percentage was higher in Group I than Group II (163/320=51% vs 22 123/52 691=42%), Kaplan-Meier curves indicate no significant difference in the time to death between the two groups (P=.92).

CONCLUSIONS

There is little risk of transmission of the common nonaggressive CNS tumors to recipients of thoracic organs.

摘要

背景

我们分析了器官共享联合网络（UNOS）数据库，以更好地确定中枢神经系统（CNS）肿瘤从供体传播至成年胸段器官受体的风险。

方法

数据取自标准移植分析与研究数据集文件。识别出患有中枢神经系统肿瘤的供体，来自这些供体的受体组成研究组（I组）。来自没有中枢神经系统肿瘤的供体的其余器官受体形成对照组（II组）。计算并比较受体中枢神经系统肿瘤的发病率、与供体相关的恶性肿瘤以及总生存率，并进行多变量逻辑回归分析。

结果

纳入了58314名成年胸段器官受体队列，其中337人接受了来自有记录的中枢神经系统肿瘤供体的器官（I组）。在中位随访72个月（范围：30 - 130个月）时，这些受体均未发生中枢神经系统肿瘤。尽管I组的总体死亡率百分比高于II组（163/320 = 51% 对比 22123/52691 = 42%），但Kaplan-Meier曲线表明两组之间的死亡时间无显著差异（P = 0.92）。