萝卜硫素通过抑制细胞-细胞融合相关基因DC-STAMP、OC-STAMP和Atp6v0d2的表达来减轻破骨细胞前体细胞的多核化。
Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.
作者信息
Takagi Tomohiro, Inoue Hirofumi, Takahashi Nobuyuki, Katsumata-Tsuboi Rie, Uehara Mariko
机构信息
a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
出版信息
Biosci Biotechnol Biochem. 2017 Jun;81(6):1220-1223. doi: 10.1080/09168451.2017.1281729. Epub 2017 Jan 30.
We assessed the effect of sulforaphene (SFE) on osteoclast differentiation. SFE significantly decreased the number of RANKL-induced tartrate-resistant acid phosphatase-positive cells and suppressed pre-osteoclast multinucleation. Furthermore, SFE downregulated mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules. Our data suggest that SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion.
我们评估了萝卜硫素（SFE）对破骨细胞分化的影响。SFE显著减少了RANKL诱导的抗酒石酸酸性磷酸酶阳性细胞的数量，并抑制了前破骨细胞多核化。此外，SFE下调了编码细胞-细胞融合分子的DC-STAMP、OC-STAMP和Atp6v0d2的mRNA表达。我们的数据表明，SFE通过抑制细胞-细胞融合来减弱前破骨细胞多核化。
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