胃癌腹腔游离癌细胞：腹膜癌病的病理学及胃癌腹腔化疗/腹腔热灌注化疗的理论依据
Intraperitoneal free cancer cells in gastric cancer: pathology of peritoneal carcinomatosis and rationale for intraperitoneal chemotherapy/hyperthermic intraperitoneal chemotherapy in gastric cancer.
作者信息
Ji Zhong-He, Peng Kai-Wen, Li Yan
机构信息
Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital affiliated to the Capital Medical University, Beijing 100038, China.
出版信息
Transl Gastroenterol Hepatol. 2016 Sep 19;1:69. doi: 10.21037/tgh.2016.08.03. eCollection 2016.
Abstract
Peritoneal carcinomatosis (PC) is one of the most common causes of death in gastric cancer patients. Intraperitoneal free cancer cells (IFCCs) play a very important role in forming PC, but the administration of intraperitoneal chemotherapy (IPC) and/or hyperthermic intraperitoneal chemotherapy (HIPEC) could be an effective treatment for IFCCs. This review focuses on the origin of IFCCs, the mechanism of PC formatting, the rationale of IPC/HIPEC, and the current clinical trials on IPC/HIPEC to treat advanced gastric cancer patients.
摘要
腹膜癌病（PC）是胃癌患者最常见的死亡原因之一。腹腔内游离癌细胞（IFCCs）在形成PC过程中起着非常重要的作用，但腹腔内化疗（IPC）和/或热灌注腹腔内化疗（HIPEC）可能是治疗IFCCs的有效方法。本综述重点关注IFCCs的起源、PC形成机制、IPC/HIPEC的理论依据以及目前关于IPC/HIPEC治疗晚期胃癌患者的临床试验。
相似文献
1
Intraperitoneal free cancer cells in gastric cancer: pathology of peritoneal carcinomatosis and rationale for intraperitoneal chemotherapy/hyperthermic intraperitoneal chemotherapy in gastric cancer.胃癌腹腔游离癌细胞：腹膜癌病的病理学及胃癌腹腔化疗/腹腔热灌注化疗的理论依据
Transl Gastroenterol Hepatol. 2016 Sep 19;1:69. doi: 10.21037/tgh.2016.08.03. eCollection 2016.
2
Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study.胃癌患者腹膜播散的细胞减灭术和腹腔内热灌注化疗（HIPEC）治疗：PERISCOPE研究的原理与设计
JMIR Res Protoc. 2017 Jul 13;6(7):e136. doi: 10.2196/resprot.7790.
3
Treatment and prevention of peritoneal carcinomatosis from gastric cancer by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: overview and rationale.细胞减灭术和腹腔热灌注化疗治疗和预防胃癌腹膜转移癌：概述和原理。
Eur J Surg Oncol. 2013 Dec;39(12):1309-16. doi: 10.1016/j.ejso.2013.10.010. Epub 2013 Oct 23.
4
Intraperitoneal chemotherapy for locally advanced gastric cancer to prevent and treat peritoneal carcinomatosis.腹腔内化疗用于局部晚期胃癌以预防和治疗腹膜种植转移。
Transl Gastroenterol Hepatol. 2016 Aug 9;1:62. doi: 10.21037/tgh.2016.07.04. eCollection 2016.
5
Role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer.减瘤手术及腹腔内热灌注化疗在胃癌治疗中的作用
Cir Cir. 2018;86(3):277-284. doi: 10.24875/CIRU.M18000040.
6
The 30-year experience-A meta-analysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer.30年经验——热腹腔内化疗治疗胃癌的随机及高质量非随机研究的荟萃分析
Eur J Cancer. 2017 Jul;79:1-14. doi: 10.1016/j.ejca.2017.03.030. Epub 2017 Apr 26.
7
Peritoneal carcinomatosis from unusual cancer origins: Is there a role for hyperthermic intraperitoneal chemotherapy?罕见癌症起源导致的腹膜癌转移：腹腔内热灌注化疗是否起作用？
J Visc Surg. 2016 Apr;153(2):101-7. doi: 10.1016/j.jviscsurg.2015.11.010. Epub 2015 Dec 11.
8
Rationale for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis.腹腔热灌注化疗（HIPEC）在治疗或预防腹膜癌病中的理论依据。
Acta Chir Belg. 2004 Aug;104(4):377-83.
9
Laparoscopic HIPEC for Peritoneal Carcinomatosis from Gastric Cancer - Technique and Early Outcomes of Our First Cases.腹腔镜热灌注化疗治疗胃癌腹膜转移癌——首例病例的技术与早期结果
Chirurgia (Bucur). 2017 Nov-Dec;112(6):714-725. doi: 10.21614/chirurgia.112.6.714.
10
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis.减瘤手术及腹腔热灌注化疗治疗伴有腹膜转移的胃癌
Chin J Cancer Res. 2017 Feb;29(1):86-92. doi: 10.21147/j.issn.1000-9604.2017.01.10.
引用本文的文献
1
Correlation between laparoscopic radical resection and tumor markers in peritoneal irrigation fluid.腹腔镜根治性切除术与腹腔冲洗液中肿瘤标志物的相关性
World J Gastrointest Surg. 2025 Aug 27;17(8):109155. doi: 10.4240/wjgs.v17.i8.109155.
2
Case report: A case of high grade serous carcinoma of peritoneal origin.病例报告：一例原发性腹膜高级别浆液性癌。
Front Oncol. 2024 Mar 25;14:1323650. doi: 10.3389/fonc.2024.1323650. eCollection 2024.
3
A Preliminary Study of Immediate Intraperitoneal Chemotherapy for Stage III Colorectal Cancer.III 期结直肠癌即刻腹腔化疗的初步研究。
Am J Clin Oncol. 2023 May 1;46(5):193-198. doi: 10.1097/COC.0000000000000980. Epub 2023 Mar 30.
4
Feasibility and Safety of Laparoscopic D2 Gastrectomy in Combination with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Gastric Cancer at High Risk of Recurrence-The PIPAC-OPC4 Study.腹腔镜 D2 胃切除术联合加压腹腔内气溶胶化疗（PIPAC）治疗高复发风险胃癌患者的可行性和安全性：PIPAC-OPC4 研究。
Ann Surg Oncol. 2023 Jul;30(7):4433-4441. doi: 10.1245/s10434-023-13278-w. Epub 2023 Mar 3.
5
Ferroptosis-Inducing Nanomedicine for Cancer Therapy.用于癌症治疗的铁死亡诱导纳米药物
Front Pharmacol. 2021 Dec 20;12:735965. doi: 10.3389/fphar.2021.735965. eCollection 2021.
6
Intra-operative hyperthermic intraperitoneal chemotherapy for prevention and treatment of peritoneal metastases from gastric cancer: a narrative review.术中腹腔内热灌注化疗预防和治疗胃癌腹膜转移：一项叙述性综述
J Gastrointest Oncol. 2021 Apr;12(Suppl 1):S70-S78. doi: 10.21037/jgo-20-262.
7
A case report of appendix mucinous adenocarcinoma that recurred after additional surgery and a brief literature review.阑尾黏液性腺癌术后复发 1 例并文献复习
BMC Surg. 2020 Aug 10;20(1):182. doi: 10.1186/s12893-020-00842-4.
8
Free cancer cells in gastric cancer - methods of detection, clinical and prognostic importance (meta-analysis).胃癌中的游离癌细胞——检测方法、临床及预后意义（荟萃分析）
Contemp Oncol (Pozn). 2020;24(1):67-74. doi: 10.5114/wo.2020.94724. Epub 2020 Mar 30.
9
Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells.热疗增强顺铂对 OVCAR-3 细胞的细胞毒性和对线粒体功能的不良影响。
J Bioenerg Biomembr. 2019 Aug;51(4):301-310. doi: 10.1007/s10863-019-09805-8. Epub 2019 Jul 22.
10
Could texture features from preoperative CT image be used for predicting occult peritoneal carcinomatosis in patients with advanced gastric cancer?术前 CT 图像纹理特征能否用于预测晚期胃癌患者的隐匿性腹膜癌病？
PLoS One. 2018 Mar 29;13(3):e0194755. doi: 10.1371/journal.pone.0194755. eCollection 2018.
本文引用的文献
1
Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies.中国腹膜恶性肿瘤减瘤手术与腹腔热灌注化疗专家共识
World J Gastroenterol. 2016 Aug 14;22(30):6906-16. doi: 10.3748/wjg.v22.i30.6906.
2
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of gastrointestinal cancers with peritoneal metastases: Progress toward a new standard of care.细胞减灭术和腹腔热灌注化疗治疗胃肠道癌腹膜转移：迈向新的治疗标准的进展。
Cancer Treat Rev. 2016 Jul;48:42-9. doi: 10.1016/j.ctrv.2016.06.007. Epub 2016 Jun 16.
3
Patterns of Care for Colorectal Liver Metastasis Within an Integrated Health System: Secular Trends and Outcomes.综合医疗体系中结直肠癌肝转移的治疗模式：长期趋势与治疗结果
Ann Surg Oncol. 2017 Jan;24(1):23-30. doi: 10.1245/s10434-016-5351-8. Epub 2016 Jun 24.
4
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center.细胞减灭术联合洛铂与多西他赛腹腔热灌注化疗治疗胃癌同步性腹膜转移癌：来自中国一家中心的结果
Eur J Surg Oncol. 2016 Jul;42(7):1024-34. doi: 10.1016/j.ejso.2016.04.053. Epub 2016 May 3.
5
A comprehensive treatment for peritoneal metastases from gastric cancer with curative intent.以治愈为目的的胃癌腹膜转移综合治疗。
Eur J Surg Oncol. 2016 Aug;42(8):1123-31. doi: 10.1016/j.ejso.2016.03.016. Epub 2016 Apr 9.
6
What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1,125 procedures.是什么使热灌注腹腔化疗成为腹膜表面恶性肿瘤的有效治愈性治疗方法：25年1125例手术的经验。
J Surg Oncol. 2016 Jun;113(7):796-803. doi: 10.1002/jso.24248. Epub 2016 Apr 25.
7
Assessment of Hyperthermic Intraperitoneal Chemotherapy to Eradicate Intraperitoneal Free Cancer Cells.评估腹腔内热灌注化疗以根除腹腔游离癌细胞。
Transl Oncol. 2016 Feb;9(1):18-24. doi: 10.1016/j.tranon.2015.11.015. Epub 2016 Jan 23.
8
Feasibility of weekly intraperitoneal versus intravenous paclitaxel therapy delivered from the day of radical surgery for gastric cancer: a preliminary safety analysis of the INPACT study, a randomized controlled trial.胃癌根治术后从当日起每周腹腔内注射与静脉注射紫杉醇治疗的可行性：INPACT研究的初步安全性分析，一项随机对照试验
Gastric Cancer. 2017 Jan;20(1):190-199. doi: 10.1007/s10120-016-0598-0. Epub 2016 Feb 15.
9
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer.胃癌的细胞减灭术及腹腔内热灌注化疗
World J Gastroenterol. 2016 Jan 21;22(3):1114-30. doi: 10.3748/wjg.v22.i3.1114.
10
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: long-term results at St George Hospital, Australia.肿瘤细胞减灭术及腹腔热灌注化疗：澳大利亚圣乔治医院的长期结果
ANZ J Surg. 2016 Nov;86(11):937-941. doi: 10.1111/ans.13152. Epub 2015 Jul 14.
Zotero 插件