Wang Zhan, Zhang Kun, Zhu Yangjun, Wang Dengfeng, Shao Yuxiong, Zhang Jun
Department of Orthopaedics, Hong Hui Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710054, P.R. China.
Mol Med Rep. 2017 Apr;15(4):1747-1752. doi: 10.3892/mmr.2017.6159. Epub 2017 Jan 30.
Curcumin is a biologically active ingredient abundantly present in the ground rhizomes of Curcuma longa with a wide range of bioactive properties, including antitumor effects. Hypoxia is a common characteristic of solid tumors, including osteosarcoma. However, whether curcumin has antitumor effects on osteosarcoma under hypoxic conditions, and its underlying molecular mechanisms, remain unclear. The present study demonstrated that the MG‑63 osteosarcoma cell line exhibited increased proliferation and enhanced invasiveness upon exposure to hypoxic conditions. However, these effects were prevented by curcumin treatment. Further investigation revealed that curcumin may inhibit Notch1 upregulation induced by hypoxia. Overexpression of Notch1 via Notch1 cDNA transfection ameliorated curcumin‑inhibited MG‑63 cell growth under hypoxic conditions. Taken together, these data revealed that curcumin may suppress the growth of osteosarcoma cells in hypoxia via inhibiting Notch1 signaling.
姜黄素是一种生物活性成分，大量存在于姜黄的地下根茎中，具有广泛的生物活性特性，包括抗肿瘤作用。缺氧是实体瘤（包括骨肉瘤）的一个常见特征。然而，姜黄素在缺氧条件下对骨肉瘤是否具有抗肿瘤作用及其潜在的分子机制仍不清楚。本研究表明，MG-63骨肉瘤细胞系在暴露于缺氧条件下时增殖增加且侵袭性增强。然而，这些作用可通过姜黄素处理来预防。进一步研究发现，姜黄素可能抑制缺氧诱导的Notch1上调。通过Notch1 cDNA转染过表达Notch1可改善姜黄素在缺氧条件下对MG-63细胞生长的抑制作用。综上所述，这些数据表明姜黄素可能通过抑制Notch1信号传导来抑制缺氧条件下骨肉瘤细胞的生长。
