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基于树突状细胞疫苗的胶质母细胞瘤免疫疗法的发展。

The development of dendritic cell vaccine-based immunotherapies for glioblastoma.

机构信息

Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Dana 2134, Boston, MA, 02215-5450, USA.

Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, 32605, USA.

出版信息

Semin Immunopathol. 2017 Feb;39(2):225-239. doi: 10.1007/s00281-016-0616-7. Epub 2017 Jan 30.

DOI:10.1007/s00281-016-0616-7
PMID:28138787
Abstract

In this review, we focus on the biologic advantages of dendritic cell-based vaccinations as a therapeutic strategy for cancer as well as preclinical and emerging clinical data associated with such approaches for glioblastoma patients.

摘要

在这篇综述中,我们专注于基于树突状细胞的疫苗接种作为癌症治疗策略的生物学优势,以及与胶质母细胞瘤患者的这种方法相关的临床前和新兴临床数据。

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The development of dendritic cell vaccine-based immunotherapies for glioblastoma.基于树突状细胞疫苗的胶质母细胞瘤免疫疗法的发展。
Semin Immunopathol. 2017 Feb;39(2):225-239. doi: 10.1007/s00281-016-0616-7. Epub 2017 Jan 30.
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Should dendritic cell-based tumor vaccination be incorporated into standard therapy for newly diagnosed glioblastoma patients?基于树突状细胞的肿瘤疫苗接种是否应纳入新诊断胶质母细胞瘤患者的标准治疗中?
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本文引用的文献

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Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses.树突状细胞向淋巴结的迁移及其增强以驱动抗肿瘤反应。
Crit Rev Oncol Hematol. 2016 Nov;107:100-110. doi: 10.1016/j.critrevonc.2016.09.002. Epub 2016 Sep 9.
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Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach.采用癌症免疫基因组学方法在两种脑胶质瘤模型中鉴定内源性新抗原特异性 CD8 T 细胞。
Cancer Immunol Res. 2016 Dec;4(12):1007-1015. doi: 10.1158/2326-6066.CIR-16-0156. Epub 2016 Oct 31.
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Gene-modified dendritic cell vaccines for cancer.
基于细胞的免疫疗法治疗脑胶质瘤患者的疗效:系统评价和荟萃分析的伞状评价方案。
BMJ Open. 2023 Dec 28;13(12):e072484. doi: 10.1136/bmjopen-2023-072484.
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Advancements in dendritic cell vaccination: enhancing efficacy and optimizing combinatorial strategies for the treatment of glioblastoma.树突状细胞疫苗接种的进展:提高治疗胶质母细胞瘤的疗效并优化联合策略
Front Neurol. 2023 Oct 31;14:1271822. doi: 10.3389/fneur.2023.1271822. eCollection 2023.
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The Current Status, Challenges, and Future Potential of Therapeutic Vaccination in Glioblastoma.胶质母细胞瘤治疗性疫苗的现状、挑战及未来潜力
Pharmaceutics. 2023 Apr 3;15(4):1134. doi: 10.3390/pharmaceutics15041134.
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Immunotherapy associated central nervous system complications in primary brain tumors.原发性脑肿瘤中免疫治疗相关的中枢神经系统并发症
Front Oncol. 2023 Feb 16;13:1124198. doi: 10.3389/fonc.2023.1124198. eCollection 2023.
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Pharmacological inhibition of the ubiquitin-specific protease 8 effectively suppresses glioblastoma cell growth.泛素特异性蛋白酶8的药理学抑制有效抑制胶质母细胞瘤细胞生长。
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