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儿童时期体重指数变化与各种哮喘表型风险的关系:一项回顾性分析。

Changes in body mass index during childhood and risk of various asthma phenotypes: a retrospective analysis.

机构信息

Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France.

Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France.

出版信息

Pediatr Allergy Immunol. 2017 May;28(3):273-279. doi: 10.1111/pai.12699. Epub 2017 Mar 6.

Abstract

BACKGROUND

It is known that asthma is related to obesity but also to small birthweight. The objective of this study was to clarify this issue by assessing the putative relationship between the changes in corpulence between birth and childhood as assessed by body mass index (BMI) and asthma phenotypes.

METHODS

The following status in corpulence was assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11 years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10, and the reference group constituted by all the other children in whom corpulence changes were not extreme. Determination of asthma phenotypes (allergic, non-allergic, and exercise-induced asthma) was based on a clinical examination including skin prick tests, an exercise challenge test, and a questionnaire.

RESULTS

The risk of allergic asthma was higher in children with persistent underweight, children with persistent overweight, and children becoming markedly more corpulent. In boys, the risk of allergic asthma was significantly higher for the less corpulent children at birth, regardless of whether they remained so or become overweight. In girls, the risk of allergic asthma was significantly higher in those with persistent overweight. There were no significant associations between BMI changes and non-allergic and exercise-induced asthma.

CONCLUSIONS

We observed that some extreme changes in BMI, persistent underweight, and persistent overweight in childhood increased the risk of allergic asthma.

摘要

背景

已知哮喘与肥胖有关,但也与出生体重小有关。本研究的目的是通过评估出生和儿童期之间肥胖变化(通过体重指数 (BMI) 评估)与哮喘表型之间的潜在关系来澄清这个问题。

方法

使用出生时和大约 10 岁(9-11 岁)时 BMI 的四分位数评估 7781 名学童的以下肥胖状态:出生和大约 10 岁时体重不足、出生时体重不足和大约 10 岁时超重、出生时超重和大约 10 岁时体重不足、出生时超重和大约 10 岁时超重,以及由肥胖变化不极端的所有其他儿童组成的参考组。哮喘表型(过敏性、非过敏性和运动性哮喘)的确定基于包括皮肤点刺试验、运动挑战试验和问卷调查在内的临床检查。

结果

持续体重不足、持续超重和体重明显增加的儿童患过敏性哮喘的风险更高。在男孩中,无论他们是否仍然如此或超重,出生时体重较轻的儿童患过敏性哮喘的风险显著更高。在女孩中,持续超重的儿童患过敏性哮喘的风险显著更高。BMI 变化与非过敏性和运动性哮喘之间没有显著关联。

结论

我们观察到,BMI 的一些极端变化、持续体重不足和儿童期持续超重会增加过敏性哮喘的风险。

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