Department of Clinical Epidemiology, Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Department of Clinical Epidemiology, Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
BMC Pediatr. 2018 Apr 26;18(1):143. doi: 10.1186/s12887-018-1093-z.
Asthma is a multifactorial syndrome that threatens the health of children. Body mass index (BMI) might be one of the potential factors but the evidence is controversial. The aim of this study is to perform a comprehensive meta-analysis to investigate the association between asthma and BMI.
Electronic databases including, Web of Science, Pubmed, Scopus, Science Direct, ProQuest, up to April 2017, were searched by two researchers independently. The keywords "asthma, body mass index, obesity, overweight, childhood and adolescence" were used. Random and fixed effects models were applied to obtain the overall odds ratios (ORs) and standardized mean difference (SMD). Heterogeneity between the studies was examined using I and Cochrane Q statistics.
After reviewing 2511 articles, 16 studies were eligible for meta-analysis according to inclusion/exclusion criteria. A meta-analysis from 11 case-control studies revealed OR of asthma and overweight as OR = 1.64; (95% Confidence Interval (CI): 1.13-2.38) and from 14 case-control studies, OR for asthma and obesity was OR = 1.92 (95% CI: 1.39-2.65), which indicated that risk of asthma in overweight and obese children and adolescence was significantly higher (1.64 and 1.92 times) than that of individuals with (p-value < 0.01 for underweight/normal weight in both cases). Furthermore, there was a significant relationship between asthma and BMI > 85 percentile according to SMD SMD = 0.21; (95%CI: 0.03-0.38; p-value = 0.021).
The results showed a significant relationship between BMI (obesity/overweight) and asthma among children and adolescents. It is important to study the confounding factors that affect the relationship between asthma and BMI in future epidemiological researches.
哮喘是一种威胁儿童健康的多因素综合征。体重指数（BMI）可能是其中一个潜在因素，但证据存在争议。本研究旨在进行综合荟萃分析，以调查哮喘与 BMI 之间的关系。
研究人员独立检索了包括 Web of Science、PubMed、Scopus、Science Direct、ProQuest 在内的电子数据库，检索时间截至 2017 年 4 月。使用的关键词为“asthma、body mass index、obesity、overweight、childhood 和 adolescence”。采用随机和固定效应模型计算总比值比（OR）和标准化均数差（SMD）。采用 I ²和 Cochrane Q 统计检验评估研究间的异质性。
在对 2511 篇文章进行综述后，根据纳入/排除标准，有 16 项研究符合荟萃分析的条件。对 11 项病例对照研究的荟萃分析显示，哮喘与超重的比值比（OR）为 1.64（95%置信区间（CI）：1.13-2.38），而对 14 项病例对照研究的荟萃分析显示，哮喘与肥胖的 OR 为 1.92（95%CI：1.39-2.65），这表明超重和肥胖儿童和青少年患哮喘的风险显著更高（分别为 1.64 和 1.92 倍）（p 值均<0.01）。此外，根据 SMD 显示，哮喘与 BMI>85 百分位数之间存在显著关系（SMD=0.21；95%CI：0.03-0.38；p 值=0.021）。
结果表明，BMI（肥胖/超重）与儿童和青少年哮喘之间存在显著关系。未来的流行病学研究中，有必要研究影响哮喘与 BMI 之间关系的混杂因素。
