从南非新分离出与狂犬病相关的莫科拉病毒。
New isolations of the rabies-related Mokola virus from South Africa.
作者信息
Coertse Jessica, Markotter Wanda, le Roux Kevin, Stewart Daniel, Sabeta Claude T, Nel Louis H
机构信息
Center for Viral Zoonoses, Department of Medical Virology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, 0001, South Africa.
Allerton Provincial Veterinary Laboratory, Pietermaritzburg, KwaZulu-Natal, 3200, South Africa.
出版信息
BMC Vet Res. 2017 Jan 31;13(1):37. doi: 10.1186/s12917-017-0948-0.
BACKGROUND
Mokola virus (MOKV) is a rabies-related lyssavirus and appears to be exclusive to the African continent. Only 24 cases of MOKV, which includes two human cases, have been reported since its identification in 1968. MOKV has an unknown reservoir host and current commercial vaccines do not confer protection against MOKV.
RESULTS
We describe three new isolations of MOKV from domestic cats in South Africa. Two cases were retrospectively identified from 2012 and an additional one in 2014.
CONCLUSIONS
These cases emphasize the generally poor surveillance for rabies-related lyssaviruses and our inadequate comprehension of the epidemiology and ecology of Mokola lyssavirus per se.
背景
莫科拉病毒（MOKV）是一种与狂犬病相关的狂犬病病毒，似乎仅在非洲大陆存在。自1968年被发现以来，仅报告了24例莫科拉病毒病例，其中包括两例人类病例。莫科拉病毒的储存宿主不明，目前的商业疫苗对莫科拉病毒没有保护作用。
结果
我们描述了从南非家猫中分离出的三株新的莫科拉病毒。其中两例是对2012年病例的回顾性鉴定，另外一例为2014年的病例。
结论
这些病例凸显了对与狂犬病相关的狂犬病病毒普遍监测不力，以及我们对莫科拉狂犬病病毒本身的流行病学和生态学认识不足。
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