Lau King Hang Aaron, Castelletto Valeria, Kendall Thomas, Sefcik Jan, Hamley Ian W, Reza Mehedi, Ruokolainen Janne
WestCHEM/Department of Pure & Applied Chemistry, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Chem Commun (Camb). 2017 Feb 9;53(13):2178-2181. doi: 10.1039/c6cc09888f.
Poly(N-substituted glycine) "peptoids" constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.
聚（N-取代甘氨酸）“类肽”构成了一类很有前景的肽模拟材料。我们通过改变类肽序列设计，将脂类肽自组装成直径约5纳米的球形胶束以及更大的聚集体。我们的结果指出了类肽纳米结构自组装的设计规则，能够创造出稳定的超小型肽模拟纳米球。
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