Toward Harnessing Sex Steroid Signaling as a Therapeutic Target in Pulmonary Arterial Hypertension.
作者信息
Lahm Tim, Frump Andrea L
机构信息
1 Division of Pulmonary, Critical Care, Occupational and Sleep Medicine Indiana University School of Medicine Indianapolis, Indiana.
2 Richard L. Roudebush VA Medical Center Indianapolis, Indiana.
出版信息
Am J Respir Crit Care Med. 2017 Feb 1;195(3):284-286. doi: 10.1164/rccm.201609-1906ED.
Abstract
摘要
相似文献
1
Toward Harnessing Sex Steroid Signaling as a Therapeutic Target in Pulmonary Arterial Hypertension.将性类固醇信号传导作为肺动脉高压治疗靶点的研究进展
Am J Respir Crit Care Med. 2017 Feb 1;195(3):284-286. doi: 10.1164/rccm.201609-1906ED.
2
BET Signaling: A Novel Therapeutic Target for Pulmonary Hypertension?溴结构域和额外末端结构域（BET）信号传导：肺动脉高压的新型治疗靶点？
Am J Respir Crit Care Med. 2020 May 15;201(10):1313. doi: 10.1164/rccm.201912-2525LE.
3
Reply to Chen : BET Signaling: A Novel Therapeutic Target for Pulmonary Hypertension?对陈的回复：BET信号传导：肺动脉高压的新型治疗靶点？
Am J Respir Crit Care Med. 2020 May 15;201(10):1313-1314. doi: 10.1164/rccm.202001-0059LE.
4
Pulmonary Arterial Hypertension and the Sex Hormone Paradox.肺动脉高压与性激素悖论。
Curr Hypertens Rep. 2016 Nov;18(11):84. doi: 10.1007/s11906-016-0689-7.
5
Sex Differences and the Role of Sex Hormones in Pulmonary Hypertension.性别差异及性激素在肺动脉高压中的作用。
Clin Chest Med. 2021 Sep;42(3):457-465. doi: 10.1016/j.ccm.2021.04.006.
6
The adrenergic nervous system as a therapeutic target in pulmonary arterial hypertension: a cautionary tale.肾上腺素能神经系统作为肺动脉高压的治疗靶点：一则警示故事。
Eur Respir J. 2016 Sep;48(3):617-8. doi: 10.1183/13993003.01333-2016.
7
Protease-activated receptor 1 as potential therapeutic target in pulmonary arterial hypertension.
Cardiovasc Res. 2019 Jul 1;115(8):1260-1261. doi: 10.1093/cvr/cvz071.
8
[PRIMARY PULMONARY ARTERIAL HYPERTENSION. APROPOS OF 8 PERSONAL OBSERVATIONS].[原发性肺动脉高压。基于8例个人观察病例]
Mal Cardiovasc. 1965;6:121-38.
9
Role for DNA damage signaling in pulmonary arterial hypertension.DNA 损伤信号在肺动脉高压中的作用。
Circulation. 2014 Feb 18;129(7):786-97. doi: 10.1161/CIRCULATIONAHA.113.006167. Epub 2013 Nov 22.
10
Baloon atrial septostomy in pulmonary arterial hypertension: Atrial flow regulator - New therapeutic option.肺动脉高压中的球囊房间隔造口术：心房血流调节器——新的治疗选择。
Cardiol J. 2017;24(4):455-456. doi: 10.5603/CJ.2017.0094.
引用本文的文献
1
Sex, hormones, and lung health.性别、激素与肺部健康。
Physiol Rev. 2025 Aug 6. doi: 10.1152/physrev.00026.2024.
2
Sex and Gender Differences in Lung Disease.性别与肺部疾病差异
Adv Exp Med Biol. 2021;1304:227-258. doi: 10.1007/978-3-030-68748-9_14.
3
Association of premature menopause with incident pulmonary hypertension: A cohort study.早绝经与肺动脉高压发病的相关性：一项队列研究。
PLoS One. 2021 Mar 10;16(3):e0247398. doi: 10.1371/journal.pone.0247398. eCollection 2021.
4
17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.17β-雌二醇和雌激素受体 α 通过 BMPR2 和 apelin 保护肺动脉高压患者的右心功能。
J Clin Invest. 2021 Mar 15;131(6). doi: 10.1172/JCI129433.
5
Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism.肺动脉高压时右心室功能障碍的分子机制：聚焦于冠状血管、性激素和糖/脂代谢
Cardiovasc Diagn Ther. 2020 Oct;10(5):1522-1540. doi: 10.21037/cdt-20-404.
6
The Y Chromosome Takes the Field to Modify BMPR2 Expression.Y染色体参与调控骨形态发生蛋白受体2（BMPR2）的表达。
Am J Respir Crit Care Med. 2018 Dec 15;198(12):1476-1478. doi: 10.1164/rccm.201809-1682ED.
本文引用的文献
1
Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial.阿那曲唑治疗肺动脉高压：一项随机、双盲、安慰剂对照试验
Am J Respir Crit Care Med. 2017 Feb 1;195(3):360-368. doi: 10.1164/rccm.201605-1024OC.
2
17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.17β-雌二醇介导重度肺动脉高压雌性大鼠右心室功能对急性剧烈运动的更好适应。
Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L375-88. doi: 10.1152/ajplung.00132.2016. Epub 2016 Jun 10.
3
Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.雌激素代谢物16α-羟基雌酮通过微小RNA-29介导的细胞代谢调节加重II型骨形态发生蛋白受体相关的肺动脉高压。
Circulation. 2016 Jan 5;133(1):82-97. doi: 10.1161/CIRCULATIONAHA.115.016133. Epub 2015 Oct 20.
4
Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.雌二醇改善重度血管增殖性肺动脉高压大鼠的右心室功能：内源性和外源性性激素的作用
Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L873-90. doi: 10.1152/ajplung.00006.2015. Epub 2015 Feb 20.
5
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.雌激素在肺动脉高压实验模型中对右心室功能的直接和间接保护作用
Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H273-83. doi: 10.1152/ajpheart.00758.2013. Epub 2014 Jun 6.
6
Progress in solving the sex hormone paradox in pulmonary hypertension.肺动脉高压中性激素悖论的研究进展。
Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L7-26. doi: 10.1152/ajplung.00337.2013. Epub 2014 May 9.
7
The right ventricle explains sex differences in survival in idiopathic pulmonary arterial hypertension.右心室可解释特发性肺动脉高压患者生存情况的性别差异。
Chest. 2014 Jun;145(6):1230-1236. doi: 10.1378/chest.13-1291.
8
Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA).抗凝治疗与肺动脉高压患者的生存：来自比较性、前瞻性肺动脉高压新疗法注册研究（COMPERA）的结果。
Circulation. 2014 Jan 7;129(1):57-65. doi: 10.1161/CIRCULATIONAHA.113.004526. Epub 2013 Sep 30.
9
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension.雌激素代谢酶细胞色素 P450 1B1 的活性影响肺动脉高压的发展。
Circulation. 2012 Aug 28;126(9):1087-98. doi: 10.1161/CIRCULATIONAHA.111.062927. Epub 2012 Aug 2.
10
Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study.性激素与右心室结构和功能有关：MESA 右心室研究。
Am J Respir Crit Care Med. 2011 Mar 1;183(5):659-67. doi: 10.1164/rccm.201007-1027OC. Epub 2010 Oct 1.
Zotero 插件