Rosen P P, Groshen S, Kinne D W, Hellman S
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, N.Y. 10027.
Surgery. 1989 Nov;106(5):904-10.
Among 644 patients with a small (T1) primary breast carcinoma who were followed up for a median of 18.2 years, subsequent contralateral breast carcinomas were detected in 57 of 610 women (9%) who had a contralateral breast at risk. The average annual hazard rate for contralateral carcinomas was 8/1000 patients at risk per year without significant fluctuations throughout the 20 years of follow-up. Recurrences were caused by 9 of 57 (16%) subsequent contralateral carcinomas, and 4 of the 57 patients (7%) died of recurrent contralateral carcinomas. Contralateral carcinomas were responsible for 5.1% (9 of 176) of all recurrences of breast carcinomas and 2.6% (4 of 153) of breast carcinoma deaths. Surveillance of the contralateral breast must continue throughout a patient's lifetime. Detection and treatment of subsequent lesions at an early stage is a beneficial result of follow-up, especially in women whose first carcinoma is likely to have been cured.
在644例患有小（T1）期原发性乳腺癌且中位随访时间为18.2年的患者中，在610名有对侧乳腺风险的女性中，有57例（9%）检测到了对侧乳腺癌。对侧乳腺癌的平均年风险率为每年每1000名有风险的患者中有8例，在20年的随访期间无显著波动。57例后续对侧乳腺癌中有9例（16%）导致复发，57例患者中有4例（7%）死于对侧乳腺癌复发。对侧乳腺癌占所有乳腺癌复发的5.1%（176例中的9例）和乳腺癌死亡的2.6%（153例中的4例）。必须在患者的一生中持续对其对侧乳腺进行监测。早期发现并治疗后续病变是随访的有益结果，尤其是对于那些首例癌症可能已治愈的女性。
