Basturk Ahmet, Yılmaz Aygen, Sayar Ersin, Dinçkan Ayhan, Aliosmanoğlu İbrahim, Erbiş Halil, Aydınlı Bülent, Artan Reha
Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey.
Clinic of Pediatrics, Konya Training and Research Hospital, Konya, Turkey.
Eurasian J Med. 2016 Oct;48(3):209-212. doi: 10.5152/eurasianjmed.2016.0147.
The aim of our study was to evaluate our liver transplant pediatric patients and to report our experience in the complications and the long-term follow-up results.
Patients between the ages of 0 and 18 years, who had liver transplantation in the organ transplantation center of our university hospital between 1997 and 2016, were included in the study. The age, sex, indications for the liver transplantation, complications after the transplantation, and long-term follow-up findings were retrospectively evaluated. The obtained results were analyzed with statistical methods.
In our organ transplantation center, 62 pediatric liver transplantations were carried out since 1997. The mean age of our patients was 7.3 years (6.5 months-17 years). The 4 most common reasons for liver transplantation were: Wilson's disease (n=10; 16.3%), biliary atresia (n=9; 14.5%), progressive familial intrahepatic cholestasis (n=8; 12.9%), and cryptogenic cirrhosis (n=7; 11.3%). The mortality rate after transplantation was 19.6% (12 of the total 62 patients). The observed acute and chronic rejection rates were 34% and 4.9%, respectively. Thrombosis (9.6%) was observed in the hepatic artery (4.8%) and portal vein (4.8%). Bile leakage and biliary stricture rates were 31% and 11%, respectively. 1-year and 5-year survival rates of our patients were 87% and 84%, respectively.
The morbidity and mortality rates in our organ transplantation center, regarding pediatric liver transplantations, are consistent with the literature.
本研究旨在评估我院小儿肝移植患者，并报告我们在并发症及长期随访结果方面的经验。
纳入1997年至2016年在我院大学附属医院器官移植中心接受肝移植的0至18岁患者。对患者的年龄、性别、肝移植指征、移植后并发症及长期随访结果进行回顾性评估。采用统计学方法分析所得结果。
自1997年以来，我院器官移植中心共进行了62例小儿肝移植手术。患者的平均年龄为7.3岁（6.5个月至17岁）。肝移植的4个最常见原因是：威尔逊病（n = 10；16.3%）、胆道闭锁（n = 9；14.5%）、进行性家族性肝内胆汁淤积症（n = 8；12.9%）和隐源性肝硬化（n = 7；11.3%）。移植后的死亡率为19.6%（62例患者中的12例）。观察到的急性和慢性排斥反应率分别为34%和4.9%。在肝动脉（4.8%）和门静脉（4.8%）中观察到血栓形成（9.6%）。胆漏和胆道狭窄率分别为31%和11%。我们患者的1年和5年生存率分别为87%和84%。
我院器官移植中心小儿肝移植的发病率和死亡率与文献报道一致。
