Ge Jin, Verma Vivek, Hollander Andrew, Langer Corey, Simone Charles B
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
J Thorac Dis. 2016 Dec;8(12):E1589-E1593. doi: 10.21037/jtd.2016.12.102.
Radiation recall dermatitis (RRD) is an inflammatory reaction in a previously irradiated field subsequent to the administration of pharmacologic or promoting agents. Herein, we describe a 47-year-old man with NSCLC who was treated with radiotherapy and pemetrexed-based chemotherapy three years prior to developing RRD upon resumption of pemetrexed-based chemotherapy. RRD with pemetrexed is rare and consists of five cases reported thus far. Although RRD is a rare phenomenon, it should be considered in any patient with dermatologic reactions that occur at the site of previous exposure to radiation therapy. When severe, RRD can pose a significant, and possibly life-threatening, impediment to the treatment and care of oncology patients. We discuss the time course, natural history, and management of this condition, as well as a connection to internal organ involvement, such as pneumonitis in thoracic oncology patients.
放射性回忆性皮炎（RRD）是在先前接受过放射治疗的部位，在给予药物或促发剂后发生的一种炎症反应。在此，我们描述了一名47岁的非小细胞肺癌男性患者，他在三年前接受了放疗和培美曲塞化疗，在恢复基于培美曲塞的化疗后发生了RRD。培美曲塞引起的RRD很罕见，迄今为止共报道了5例。尽管RRD是一种罕见现象，但对于任何在先前接受过放射治疗的部位出现皮肤反应的患者都应予以考虑。严重时，RRD会对肿瘤患者的治疗和护理造成重大且可能危及生命的阻碍。我们讨论了这种疾病的病程、自然史、治疗方法，以及与内部器官受累的关系，如胸部肿瘤患者的肺炎。
