Mjåset B, Høivik B, Holager G
Tidsskr Nor Laegeforen. 1989 Sep 10;109(25):2535-8.
We have treated 14 patients with acute arterial thrombosis with intravenous infusion of streptokinase using a standard dosage scheme. The indication for treatment was critical ischemia due to arterial thrombosis and a presence of symptoms for less than 30 days. The arteriography showed no possibility of reconstructive vascular surgery. The results showed that this treatment is not a good alternative for this group of patients. On the same indications we also treated two patients with intra-arterial infusion of streptokinase at a dosage of 5,000 U per hour. Successful thrombolysis was achieved in both patients. Arteriograms demonstrated that the small distal vessels were opened, along with the femoro-popliteal segment, which showed significant stenosis. The patients could then be helped by reconstructive vascular surgery. We conclude that thrombolysis with intra-arterial infusion of streptokinase is a good choice as the initial treatment for this group of patients. However, the follow-up must include immediate reconstructive vascular surgery or radiological treatment with PTA.
我们采用标准剂量方案，通过静脉输注链激酶治疗了14例急性动脉血栓患者。治疗指征为动脉血栓导致的严重缺血且症状出现少于30天。血管造影显示无法进行血管重建手术。结果表明，这种治疗方法对该组患者并非理想选择。基于相同指征，我们还对2例患者进行了动脉内输注链激酶治疗，剂量为每小时5000单位。两名患者均成功实现溶栓。动脉造影显示，除了显示明显狭窄的股腘段外，远端小血管也开通了。然后可通过血管重建手术帮助这些患者。我们得出结论，动脉内输注链激酶进行溶栓是该组患者初始治疗的良好选择。然而，随访必须包括立即进行血管重建手术或经皮腔内血管成形术（PTA）的放射治疗。
