Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
作者信息
Poynter Matthew E
机构信息
Vermont Lung Center, Department of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA.
出版信息
Ann Transl Med. 2016 Dec;4(24):505. doi: 10.21037/atm.2016.11.79.
Abstract
摘要
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1
Current concepts of severe asthma.
J Clin Invest. 2016 Jul 1;126(7):2394-403. doi: 10.1172/JCI84144.
2
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial.
Lancet. 2016 Jul 2;388(10039):31-44. doi: 10.1016/S0140-6736(16)30307-5. Epub 2016 Apr 27.
3
Humanized Anti-IL-5 Antibody Therapy.
Cell. 2016 Apr 21;165(3):509. doi: 10.1016/j.cell.2016.04.020.
4
Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.
J Immunol. 2016 Feb 1;196(3):963-77. doi: 10.4049/jimmunol.1501531. Epub 2016 Jan 4.
5
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.
Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.
6
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.
Lancet Respir Med. 2015 Sep;3(9):692-701. doi: 10.1016/S2213-2600(15)00197-6. Epub 2015 Jul 28.
7
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies.
Thorax. 2015 Aug;70(8):748-56. doi: 10.1136/thoraxjnl-2014-206719. Epub 2015 May 22.
8
IL-17 in severe asthma. Where do we stand?
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1094-101. doi: 10.1164/rccm.201405-0859PP.
9
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J Cell Biochem. 2014 Dec;115(12):2055-64. doi: 10.1002/jcb.24881.
10
Aligning mouse models of asthma to human endotypes of disease.
Respirology. 2014 Aug;19(6):823-33. doi: 10.1111/resp.12315. Epub 2014 May 9.
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