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RANKL inhibitors for osteosarcoma treatment: hope and caution.

作者信息

Trinidad Eva M, González-Suárez Eva

机构信息

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, IDIBELL, Barcelona, Spain.

出版信息

Ann Transl Med. 2016 Dec;4(24):534. doi: 10.21037/atm.2016.12.10.

Abstract
摘要

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本文引用的文献

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T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities.
Front Immunol. 2016 Sep 14;7:353. doi: 10.3389/fimmu.2016.00353. eCollection 2016.
2
RANK and RANK ligand expression in primary human osteosarcoma.
J Bone Oncol. 2015 Jul 29;4(3):59-68. doi: 10.1016/j.jbo.2015.06.002. eCollection 2015 Sep.
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RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation.
Cancer Res. 2016 Oct 1;76(19):5857-5869. doi: 10.1158/0008-5472.CAN-15-2745. Epub 2016 Aug 1.
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Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
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Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine.
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RANK expression as a prognostic and predictive marker in breast cancer.
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Nat Rev Drug Discov. 2012 May;11(5):401-19. doi: 10.1038/nrd3705.
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RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis.
Cancer Res. 2012 Jun 1;72(11):2879-88. doi: 10.1158/0008-5472.CAN-12-0044. Epub 2012 Apr 10.
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RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Nature. 2010 Nov 4;468(7320):103-7. doi: 10.1038/nature09495. Epub 2010 Sep 29.
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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
J Clin Invest. 2010 Sep;120(9):3310-25. doi: 10.1172/JCI42391. Epub 2010 Aug 9.

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