Dagan Amir, Segal Gad, Tiosano Shmuel, Watad Abdulla, Neumann Shana G, Comaneshter Doron, Cohen Arnon D, Amital Howard
Department of Medicine 'T', Sheba Medical Center, Tel-Hashomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Int J Clin Pract. 2017 Mar;71(3-4). doi: 10.1111/ijcp.12929. Epub 2017 Feb 1.
The aim of this study was to evaluate if association exist between rheumatoid arthritis and malignant diseases.
A cross-sectional study was conducted comparing rheumatoid arthritis patients with age and gender matched controls regarding the proportion of patients with comorbid malignant conditions. Chi-square tests and t-tests were used for univariate analysis. A logistic regression model was used for multivariate analysis. The study was performed utilising the medical database of Clalit Health Services.
The study group included 11 782 rheumatoid arthritis patients and 57 973 controls. The total proportion of malignancies was significantly higher in the study group than in the control group (21.4% vs 11.2%; P<.001). The disease for which there was the strongest association among patients with rheumatoid arthritis was non-Hodgkin's lymphoma (1.1% vs 0.6%; P<.01). After multivariate analysis, lung cancer was not found to be significantly associated with rheumatoid arthritis.
Rheumatoid arthritis is associated with several malignant disorders, in particular non-Hodgkin's lymphoma. Appropriate measures for non-Hodgkin's lymphoma screening in this patient population should be considered.
本研究旨在评估类风湿关节炎与恶性疾病之间是否存在关联。
开展了一项横断面研究，比较类风湿关节炎患者与年龄及性别匹配的对照组中合并恶性疾病患者的比例。采用卡方检验和t检验进行单因素分析，使用逻辑回归模型进行多因素分析。该研究利用克拉利特医疗服务公司的医学数据库进行。
研究组包括11782例类风湿关节炎患者和57973例对照组。研究组中恶性肿瘤的总比例显著高于对照组（21.4%对11.2%；P<0.001）。类风湿关节炎患者中关联最强的疾病是非霍奇金淋巴瘤（1.1%对0.6%；P<0.01）。多因素分析后，未发现肺癌与类风湿关节炎有显著关联。
类风湿关节炎与多种恶性疾病相关，尤其是非霍奇金淋巴瘤。应考虑对该患者群体进行非霍奇金淋巴瘤筛查的适当措施。
