棕榈酰化在轴突生长、退化和再生中的作用。
Roles of palmitoylation in axon growth, degeneration and regeneration.
作者信息
Holland Sabrina M, Thomas Gareth M
机构信息
Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair).
Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140.
出版信息
J Neurosci Res. 2017 Aug;95(8):1528-1539. doi: 10.1002/jnr.24003. Epub 2017 Feb 2.
Abstract
The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease. © 2017 Wiley Periodicals, Inc.
摘要
蛋白质-脂质修饰棕榈酰化在神经元中发挥着重要作用，但大多数研究都集中在这种修饰对成熟突触前和突触后的调节作用上。然而，最近令人兴奋的研究结果表明，棕榈酰化对于神经元轴突的生长和完整性也至关重要，并且在传递轴突顺行和逆行信号方面发挥着以前未被认识到的作用。在这里，我们综述了棕榈酰化在健康和疾病状态下对轴突调节的这些新出现的作用。© 2017威利期刊公司。
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