Gomariz R P, De Cárdenas L, Zapat A
Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, Spain.
Tissue Cell. 1989;21(3):403-17. doi: 10.1016/0040-8166(89)90054-2.
The histological organization of the periarterial lymphoid sheath (PALS) was studied during the postnatal life of the golden hamster Mesocricetus auratus with special interest in the cell components occurring in each of their regions. Our results suggest a role of the cell components defining the splenic microenvironment at each developmental stage in governing the developmental process. This process can be temporarily and histologically divide into three stages: 1. At birth, a few lymphocytes and lymphoblasts surrounding the central artery define primitive PALS. 2. A second period is determined on the 2nd day by the appearance of a marginal sinus which bounds the two splenic compartments, white and red pulp. The PALS increases circumferentially around the central artery defined by the pattern of reticular cells and fibres. 3. Between the 4th and 10th days, the PALS reaches its definitive organization, except for the absence of primary and secondary lymphoid follicles, defining an inner and outer region. The marginal zone appears on the 6th day.
我们研究了金黄地鼠（Mesocricetus auratus）出生后动脉周围淋巴鞘（PALS）的组织学结构，特别关注其各个区域中出现的细胞成分。我们的研究结果表明，在每个发育阶段，定义脾脏微环境的细胞成分在调控发育过程中发挥着作用。这个过程在组织学上可暂时分为三个阶段：1. 出生时，围绕中央动脉的少量淋巴细胞和淋巴母细胞构成原始PALS。2. 在出生后第2天，出现界定脾白髓和红髓这两个脾区室的边缘窦，这标志着第二个阶段。PALS围绕由网状细胞和纤维构成的中央动脉呈圆周状增加。3. 在出生后第4天至第10天之间，除了没有初级和次级淋巴滤泡外，PALS达到其最终结构，界定了一个内部区域和一个外部区域。边缘区在出生后第6天出现。
