Oliveri Valentina, Bellia Francesco, Vecchio Graziella
Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy.
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B, Unit of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Chemistry. 2017 Mar 28;23(18):4442-4449. doi: 10.1002/chem.201700031. Epub 2017 Mar 8.
Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal-chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal-chelating β-cyclodextrin polymer bearing 8-hydroxyquinoline ligands. The metal ions (Cu or Zn ) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self- and metal-induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β-cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.
环糊精被用作大量聚合物生物材料开发的构建单元。环糊精聚合物因其具有机械性能、刺激响应性和药物负载能力等独特特性而有众多应用。尽管已研究的环糊精聚合物数量众多，但基于环糊精的金属螯合聚合物却鲜有探索。在此，我们报告了首例带有8-羟基喹啉配体的金属螯合β-环糊精聚合物的合成与表征。金属离子（铜或锌）可调节聚合物纳米颗粒的组装。此外，这种新型螯合聚合物对自身及金属诱导的Aβ聚集和自由基的保护活性明显高于母体化合物。这些协同效应表明，将羟基喹啉部分引入可溶性β-环糊精聚合物中可能是设计多功能生物材料的一种有前景的策略。
