Kassouf Nick, Syed Sara, Larner Joanne, Amlôt Richard, Chilcott Robert P
Research Centre for Topical Drug Delivery and Toxicology, School of Pharmacy, University of Hertfordshire, Hatfield, United Kingdom.
Microbial Risk Assessment and Behavioural Science, Public Health England, Emergency Response Department, Health Protection Directorate, Porton Down, Salisbury, Wiltshire, United Kingdom.
PLoS One. 2017 Feb 2;12(2):e0170966. doi: 10.1371/journal.pone.0170966. eCollection 2017.
The UK's Initial Operational Response (IOR) is a revised process for the medical management of mass casualties potentially contaminated with hazardous materials. A critical element of the IOR is the introduction of immediate, on-scene disrobing and decontamination of casualties to limit the adverse health effects of exposure. Ad hoc cleansing of the skin with dry absorbent materials has previously been identified as a potential means of facilitating emergency decontamination. The purpose of this study was to evaluate the in vitro oil and water absorbency of a range of materials commonly found in the domestic and clinical environments and to determine the effectiveness of a small, but representative selection of such materials in skin decontamination, using an established ex vivo model. Five contaminants were used in the study: methyl salicylate, parathion, diethyl malonate, phorate and potassium cyanide. In vitro measurements of water and oil absorbency did not correlate with ex vivo measurements of skin decontamination. When measured ex vivo, dry decontamination was consistently more effective than a standard wet decontamination method ("rinse-wipe-rinse") for removing liquid contaminants. However, dry decontamination was ineffective against particulate contamination. Collectively, these data confirm that absorbent materials such as wound dressings and tissue paper provide an effective, generic capability for emergency removal of liquid contaminants from the skin surface, but that wet decontamination should be used for non-liquid contaminants.
英国的初始行动响应(IOR)是针对可能受到有害物质污染的大规模伤亡人员进行医疗管理的修订流程。IOR的一个关键要素是对伤亡人员立即进行现场脱衣和去污,以限制接触带来的不良健康影响。此前已确定,用干燥吸水材料临时清洁皮肤是促进紧急去污的一种潜在方法。本研究的目的是评估一系列在家庭和临床环境中常见材料的体外油和水吸收能力,并使用已建立的离体模型确定一小部分但具有代表性的此类材料在皮肤去污中的有效性。该研究使用了五种污染物:水杨酸甲酯、对硫磷、丙二酸二乙酯、甲拌磷和氰化钾。水和油吸收能力的体外测量结果与皮肤去污的离体测量结果不相关。在离体测量时,干式去污在去除液体污染物方面始终比标准湿式去污方法(“冲洗-擦拭-冲洗”)更有效。然而,干式去污对颗粒污染物无效。总体而言,这些数据证实,诸如伤口敷料和纸巾等吸水材料为从皮肤表面紧急去除液体污染物提供了一种有效的通用能力,但对于非液体污染物应采用湿式去污。