McCauley D L, Tozer T N, Winter M E
Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
Ther Drug Monit. 1989 Sep;11(5):540-2.
An increase in the time required to achieve the peak plasma concentration is observed following the oral administration of increasing doses of phenytoin. Zero-order absorption is the usual explanation for this observation. The presence of Michaelis-Menten elimination also increases the peak time when absorption is first order. The contribution of each of these mechanisms in vivo is unknown.
