鼻窦小圆形蓝细胞肿瘤：一种免疫组织化学方法
Sinonasal Small Round Blue Cell Tumors: An Immunohistochemical Approach.
作者信息
Rooper Lisa M, Bishop Justin A
机构信息
Department of Pathology, The Johns Hopkins Medical Institutions, 401 North Broadway, Weinberg 2242, Baltimore, MD 21231-2410, USA.
Department of Pathology, The Johns Hopkins Medical Institutions, 401 North Broadway, Weinberg 2249, Baltimore, MD 21231-2410, USA; Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, 401 North Broadway, Weinberg 2249, Baltimore, MD 21231-2410, USA.
出版信息
Surg Pathol Clin. 2017 Mar;10(1):103-123. doi: 10.1016/j.path.2016.10.005. Epub 2016 Dec 28.
Although clinical history and morphologic appearance should be the initial considerations when evaluating small round blue cell tumors of the sinonasal tract, the final diagnosis often hinges on immunohistochemical findings. Unfortunately, interpretation of stains in these tumors is fraught with numerous pitfalls and limitations. This article presents an approach to sinonasal small round blue cell tumors based on four common immunohistochemical patterns: cytokeratin positivity, squamous marker positivity, neuroendocrine marker positivity, and cytokeratin negativity.
尽管在评估鼻窦小圆形蓝细胞肿瘤时，临床病史和形态学表现应作为首要考虑因素，但最终诊断往往取决于免疫组化结果。不幸的是，这些肿瘤中染色结果的解读存在许多陷阱和局限性。本文基于四种常见的免疫组化模式，即细胞角蛋白阳性、鳞状标志物阳性、神经内分泌标志物阳性和细胞角蛋白阴性，提出了一种针对鼻窦小圆形蓝细胞肿瘤的诊断方法。
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