喉发育异常、鳞状细胞癌及变异型

Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.

作者信息

Thompson Lester D R

机构信息

Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91367, USA.

出版信息

Surg Pathol Clin. 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003.

DOI:10.1016/j.path.2016.10.003

PMID:28153131

Abstract

Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different.

摘要

鳞状细胞癌（SCC）是一种显示鳞状分化证据的恶性上皮性肿瘤。它是喉最常见的恶性肿瘤，有几种变异型（疣状、外生性或乳头状、梭形细胞、基底样、棘层松解性、腺鳞状）已得到确认，且有公认的前驱病变。发育异常现在仅分为低级别和高级别两类。每种SCC变异型都有独特的细胞形态学特征和组织学鉴别诊断，这些都很重要，因为治疗方法和预后有所不同。