Liutkeviciene Rasa, Auzelyte Justina, Liutkevicius Vykintas, Vilkeviciute Alvita, Gedvilaite Greta, Vaiciulis Paulius, Uloza Virgilijus
Neuroscience Institute, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Biomolecules. 2022 Jul 22;12(8):1013. doi: 10.3390/biom12081013.
Recent studies have revealed that the inflammatory effect may play a significant role in various cancer development. However, this effect has still not been analyzed in patients with laryngeal squamous cell carcinoma (LSCC). In the present study, we evaluated two single nucleotide polymorphisms (SNPs) of (rs7412 and rs429358) and determined their associations with LSCC development and the LSCC patients' five-year survival rate. Additionally, we analyzed serum levels using an enzyme-linked immunosorbent assay. A total of 602 subjects (291 histologically verified LSCC patients and 311 healthy controls) were involved in this study. The genotyping was carried out using the real-time PCR. We revealed that ε3/ε3 was associated with a 1.7-fold higher probability of developing LSCC ( = 0.001), with 1.7-fold increased odds of developing LSCC without metastasis to the lymph nodes ( = 0.002) and with a 2.0-fold increased odds of developing well-differentiated LSCC ( = 0.008), as well as 1.6-fold increased odds of developing poorly differentiated LSCC development ( = 0.012). The ε2/ε4 and ε3/ε4 genotypes were associated with a 2.9-fold and 1.5-fold decrease in the likelihood of developing LSCC ( = 0.042; = 0.037, respectively). ε3/ε4 was found associated with a 2.4-fold decreased likelihood of developing well-differentiated LSCC ( = 0.013). Conclusion: ε2/ε4 and ε3/ε4 were found to play a protective role in LSCC development, while ε3/ε3 may have a risk position in LSCC development.
最近的研究表明，炎症效应可能在各种癌症的发展中起重要作用。然而，这种效应在喉鳞状细胞癌（LSCC）患者中仍未得到分析。在本研究中，我们评估了（rs7412和rs429358）的两个单核苷酸多态性（SNP），并确定了它们与LSCC发展以及LSCC患者五年生存率的关联。此外，我们使用酶联免疫吸附测定法分析了血清水平。本研究共纳入602名受试者（291名经组织学证实的LSCC患者和311名健康对照）。使用实时PCR进行基因分型。我们发现，ε3/ε3与发生LSCC的概率高1.7倍相关（P = 0.001），发生无淋巴结转移的LSCC的几率增加1.7倍（P = 0.002），发生高分化LSCC的几率增加2.0倍（P = 0.008），以及发生低分化LSCC发展的几率增加1.6倍（P = 0.012）。ε2/ε4和ε3/ε4基因型与发生LSCC的可能性分别降低2.9倍和1.5倍相关（分别为P = 0.042；P = 0.037）。发现ε3/ε4与发生高分化LSCC的可能性降低2.4倍相关（P = 0.013）。结论：发现ε2/ε4和ε3/ε4在LSCC发展中起保护作用，而ε3/ε3可能在LSCC发展中处于风险地位。
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