Skopichev V G, Skopicheva V I, Savittskiĭ G A, Shelest V N, Shteĭn G I
Tsitologiia. 1989 Jun;31(6):657-63.
A rapid growth of the uterus myoma results from the cell hypertrophy, which involves essential ultrastructural changes in the cytoplasm and the nucleus, thus suggesting the intensification cell functions. The increase in the cell volume and intensification of secretion is followed by the enlargement of the interface between the nucleus and the cytoplasm resulting in formation of numerous invaginations of the nuclear membrane. The autoradiographical data demonstrate a considerable DNA synthesis in the peripheral zone of the myoma, unlike the situation seen in the centre of the myoma and the unchanged myometrium, where DNA synthesis is not considerable. The cytospectrophotometric analysis confirms the above data showing the highest content of DNA in the peripheral zone of the myoma.
子宫肌瘤的快速生长源于细胞肥大，这涉及细胞质和细胞核中基本的超微结构变化，从而表明细胞功能增强。细胞体积的增加和分泌的增强之后是细胞核与细胞质之间界面的扩大，导致核膜形成大量内陷。放射自显影数据表明，与肌瘤中心和未改变的子宫肌层中DNA合成不显著的情况不同，肌瘤周边区域有大量DNA合成。细胞分光光度分析证实了上述数据，显示肌瘤周边区域的DNA含量最高。
