Rohold A, Nielsen H L, Hasle H
Ugeskr Laeger. 1989 Oct 9;151(41):2672.
A woman aged 60 years receiving anticoagulation treatment on account of artificial mitral and aortic valve prostheses developed severe thrombocytopenia three weeks after the commencement of quinidine treatment. The results of investigations suggested severe thrombocytopenia precipitated by quinidine. The severe thrombocytopenia persisted despite intensive treatment and the condition ended fatally on account of cerebral haemorrhage. The combination of quinidine and oral anticoagulation treatment is not unusual and it is important to bear in mind that both of these preparations may cause increased haemorrhagic tendencies.
一名60岁女性因人工二尖瓣和主动脉瓣假体接受抗凝治疗，在开始使用奎尼丁治疗三周后出现严重血小板减少症。调查结果提示奎尼丁诱发了严重血小板减少症。尽管进行了强化治疗，严重血小板减少症仍持续存在，患者最终因脑出血死亡。奎尼丁与口服抗凝治疗联合使用并不罕见，必须牢记这两种制剂都可能导致出血倾向增加。
