Jiang Zongxing, Liang Hongyin, Huang Zhu, Tang Jiajia, Tang Lijun
Department of General Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China (mainland).
Postgraduate Department, Third Military Medical University, Chongqing, China (mainland).
Med Sci Monit. 2017 Feb 3;23:623-630. doi: 10.12659/msm.903132.
BACKGROUND The correlation between sham feeding and acute pancreatitis (AP) has only been examined in limited studies. We aimed to investigate the efficacy and safety of sham feeding in the early stage of AP. MATERIAL AND METHODS A randomized controlled clinical trial was performed. Equal groups of AP patients were recruited. Patients in the sham feeding group received chewing gum 4 times a day after admission. All patients in the trial received standard treatment consistent with the guidelines for AP. The primary outcomes were mortality, length of stay (LOS), and medical expenses. Secondary outcomes were the incidence of complications and other adverse events, return of gastrointestinal function, the details of enteral nutrition and intra-abdominal pressure. RESULTS From May 2014 to December 2015, a total of 204 patients were recruited. The LOS and hospital costs in the sham feeding group were reduced, although mortality was equivalent between groups. The return of gastrointestinal function occurred earlier in the sham feeding group, with no complications related to gum chewing. CONCLUSIONS Sham feeding with chewing gum is safe and efficacious in the early stage of AP.
仅在有限的研究中探讨了假进食与急性胰腺炎（AP）之间的相关性。我们旨在研究假进食在AP早期的疗效和安全性。
进行了一项随机对照临床试验。招募了相等数量的AP患者组。假进食组的患者入院后每天咀嚼口香糖4次。试验中的所有患者均接受符合AP指南的标准治疗。主要结局指标为死亡率、住院时间（LOS）和医疗费用。次要结局指标为并发症和其他不良事件的发生率、胃肠功能恢复情况、肠内营养细节和腹内压。
2014年5月至2015年12月，共招募了204例患者。假进食组的LOS和住院费用有所降低，尽管两组之间的死亡率相当。假进食组的胃肠功能恢复较早，且无与嚼口香糖相关的并发症。
在AP早期，咀嚼口香糖进行假进食是安全有效的。
